68876-74-4 Usage
Originator
Zocainone,ZYF Pharm Chemical
Manufacturing Process
21.0 g of N,N-diethylaminoethyl chloride are added drop by drop to 35.0 g of
the sodium salt of 3-o-hydroxyphenoxy-4-phenyl-3-butene-2-one suspended
in 600 ml of anhydrous acetone. The mixture is heated under reflux for 4 h,
the sodium chloride is filtered off, and the filtrate is evaporated to dryness.
The residue is dissolved in water and extracted a number of times with diethyl
ether. The ether phase, after drying over Na 2 SO 4 , is evaporated to dryness
and purified by distillation in a bulb apparatus, and 3-[o-(β-N,N-
diethylaminoethoxy)phenoxy]-4-phenyl-3-buten-2-one was obtained, boiling
point 200-210°C/0.6 mm Hg).
Therapeutic Function
Antiarrhythmic
Check Digit Verification of cas no
The CAS Registry Mumber 68876-74-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,8,7 and 6 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 68876-74:
(7*6)+(6*8)+(5*8)+(4*7)+(3*6)+(2*7)+(1*4)=194
194 % 10 = 4
So 68876-74-4 is a valid CAS Registry Number.
InChI:InChI=1/C22H27NO3/c1-4-23(5-2)15-16-25-20-13-9-10-14-21(20)26-22(18(3)24)17-19-11-7-6-8-12-19/h6-14,17H,4-5,15-16H2,1-3H3/b22-17+
68876-74-4Relevant articles and documents
Synthesis and Antiarrhythmic Activity of New 3--4-phenyl-3-buten-2-ones and Related Compounds
Salimbeni, Aldo,Manghisi, Elso,Fregnan, Giancarlo B.,Prada, Marco
, p. 773 - 780 (2007/10/02)
A number of the title compounds (1) and a few related hydroquinone derivatives (2) have been synthesized and tested for antiarrhythmic activity in vivo (protection against CaCl2-induced ventricular fibrillation in anesthetized rat) and in vitro (ability t
Phenoxyalkylamines
-
, (2008/06/13)
The invention provides a new class of aminoalkoxyphenoxyalkenones having interesting pharmacological properties.
