688763-89-5Relevant academic research and scientific papers
Structure-activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities
Liang, Chang-Hsing,Romero, Alex,Rabuka, David,Sgarbi, Paulo W.M.,Marby, Kenneth A.,Duffield, Jonathan,Yao, Sulan,Cheng, Mayling L.,Ichikawa, Yoshi,Sears, Pamela,Hu, Changyong,Hwang, San-Bao,Shue, Youe-Kong,Sucheck, Steven J.
, p. 2123 - 2128 (2007/10/03)
A library of 4,5- and 4,6-linked bivalent aminoglycoside (AMG) antibiotics consisting of neamine and nebramine pharmacophores have been synthesized. We probed the effect of the linker on antibiotic activity with a series of selected synthetic analogues wi
Dimeric aminoglycosides as antibiotics
Agnelli, Fabio,Sucheck, Steven J.,Marby, Kenneth A.,Rabuka, David,Yao, Su-Lan,Sears, Pamela S.,Liang, Fu-Sen,Wong, Chi-Huey
, p. 1562 - 1566 (2007/10/03)
Double duty: Dimeric aminoglycoside antibiotics were designed by linking neamine or nebramine cores with various tethers differing in length and composition. The resulting dimeric aminoglycosides displayed high affinity for the 16S A site of ribosomal RNA (a representation of the complex is shown here) and were effective against various aminoglycoside-resistant bacterial strains.
