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(S)-3-AMINOHEXAN-1-OL HYDROCHLORIDE, with the CAS number 68889-62-3, is an organic compound that serves as a crucial reagent in the development of novel pyrimidine TLR7/8 dual agonists. These agonists are designed to target and treat hepatitis B, a viral infection that affects the liver.

68889-62-3

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68889-62-3 Usage

Uses

Used in Pharmaceutical Industry:
(S)-3-AMINOHEXAN-1-OL HYDROCHLORIDE is used as a reagent for the synthesis of novel pyrimidine TLR7/8 dual agonists, which are specifically designed to treat hepatitis B. (S)-3-AMINOHEXAN-1-OL HYDROCHLORIDE plays a vital role in the development of these therapeutic agents, as it contributes to the activation of immune responses against the hepatitis B virus, potentially leading to improved treatment outcomes for patients suffering from this condition.

Check Digit Verification of cas no

The CAS Registry Mumber 68889-62-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,8,8 and 9 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 68889-62:
(7*6)+(6*8)+(5*8)+(4*8)+(3*9)+(2*6)+(1*2)=203
203 % 10 = 3
So 68889-62-3 is a valid CAS Registry Number.

68889-62-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (3S)-3-aminohexan-1-ol,hydrochloride

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:68889-62-3 SDS

68889-62-3Downstream Products

68889-62-3Relevant academic research and scientific papers

Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus

McGowan, David,Herschke, Florence,Pauwels, Frederik,Stoops, Bart,Last, Stefaan,Pieters, Serge,Scholliers, Annick,Thoné, Tine,Van Schoubroeck, Bertrand,De Pooter, Dorien,Mostmans, Wendy,Khamlichi, Mourad Daoubi,Embrechts, Werner,Dhuyvetter, Deborah,Smyej, Ilham,Arnoult, Eric,Demin, Samu?l,Borghys, Herman,Fanning, Gregory,Vlach, Jaromir,Raboisson, Pierre

, p. 7936 - 7949 (2016/11/07)

Toll-like receptor (TLR) 7 and 8 agonists can potentially be used in the treatment of viral infections and are particularly promising for chronic hepatitis B virus (HBV) infection. An internal screening effort identified a pyrimidine Toll-like receptor 7 and 8 dual agonist. This provided a novel alternative over the previously reported adenine and pteridone type of agonists. Structure-activity relationship, lead optimization, in silico docking, pharmacokinetics, and demonstration of ex vivo and in vivo cytokine production of the lead compound are presented.

PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS

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Paragraph 0117; 0121; 0122; 0123; 0124; 0125, (2014/03/21)

This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.

QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES

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Paragraph 0164; 0174; 0178-0179' 0180-0182, (2014/03/25)

This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll-like-receptors is involved.

PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS

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Page/Page column 25, (2012/10/18)

This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.

QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES

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Page/Page column 37, (2012/12/13)

This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll - like - receptors is involved.

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