68889-62-3Relevant articles and documents
Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus
McGowan, David,Herschke, Florence,Pauwels, Frederik,Stoops, Bart,Last, Stefaan,Pieters, Serge,Scholliers, Annick,Thoné, Tine,Van Schoubroeck, Bertrand,De Pooter, Dorien,Mostmans, Wendy,Khamlichi, Mourad Daoubi,Embrechts, Werner,Dhuyvetter, Deborah,Smyej, Ilham,Arnoult, Eric,Demin, Samu?l,Borghys, Herman,Fanning, Gregory,Vlach, Jaromir,Raboisson, Pierre
, p. 7936 - 7949 (2016/11/07)
Toll-like receptor (TLR) 7 and 8 agonists can potentially be used in the treatment of viral infections and are particularly promising for chronic hepatitis B virus (HBV) infection. An internal screening effort identified a pyrimidine Toll-like receptor 7 and 8 dual agonist. This provided a novel alternative over the previously reported adenine and pteridone type of agonists. Structure-activity relationship, lead optimization, in silico docking, pharmacokinetics, and demonstration of ex vivo and in vivo cytokine production of the lead compound are presented.
QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES
-
Paragraph 0164; 0174; 0178-0179' 0180-0182, (2014/03/25)
This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll-like-receptors is involved.
QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES
-
Page/Page column 37, (2012/12/13)
This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll - like - receptors is involved.
