6890-65-9 Usage
Description
5-ALPHA-PREGNAN-3-ALPHA, 17-DIOL-20-ONE, also known as (3α,5α)-3,17-Dihydroxypregnan-20-one, is a naturally occurring steroidal metabolite that has garnered significant research interest due to its potential implications in various aspects of human male reproductive health. 5-ALPHA-PREGNAN-3-ALPHA, 17-DIOL-20-ONE plays a crucial role in the biosynthesis of testosterone and is associated with androgen-mediated events during male puberty. It is also linked to the development of adrenocortical carcinoma, castration-resistant prostate cancer, and urine steroid hormone profiling.
Uses
Used in Medical Research:
5-ALPHA-PREGNAN-3-ALPHA, 17-DIOL-20-ONE is used as a research compound for studying male testes diseases and aberrations related to androgen-mediated events in male puberty. Its role in the biosynthesis of testosterone and its association with various male reproductive health conditions make it a valuable tool for understanding the underlying mechanisms and potential treatments for these conditions.
Used in Endocrinology:
In the field of endocrinology, 5-ALPHA-PREGNAN-3-ALPHA, 17-DIOL-20-ONE is used as a biomarker for the diagnosis and monitoring of adrenocortical carcinoma, castration-resistant prostate cancer, and other male reproductive health issues. Its presence in urine steroid hormone profiling can provide valuable insights into the patient's hormonal balance and help guide appropriate treatment strategies.
Used in Pharmaceutical Development:
5-ALPHA-PREGNAN-3-ALPHA, 17-DIOL-20-ONE is used as a potential therapeutic agent in the development of new drugs targeting male reproductive health conditions. Its involvement in the biosynthesis of testosterone and its association with various male-specific diseases make it a promising candidate for the development of novel treatments aimed at improving male reproductive health and addressing related medical conditions.
Used in Urine Steroid Hormone Profiling:
In the field of clinical diagnostics, 5-ALPHA-PREGNAN-3-ALPHA, 17-DIOL-20-ONE is used as a key component in urine steroid hormone profiling. This technique involves the analysis of steroid hormones in urine samples to assess an individual's hormonal balance and diagnose various endocrine disorders. The presence and levels of this metabolite can provide valuable information about the patient's hormonal status and help in the early detection and management of related health issues.
Check Digit Verification of cas no
The CAS Registry Mumber 6890-65-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,9 and 0 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6890-65:
(6*6)+(5*8)+(4*9)+(3*0)+(2*6)+(1*5)=129
129 % 10 = 9
So 6890-65-9 is a valid CAS Registry Number.
6890-65-9Relevant articles and documents
STUDY OF THE DIRECT EFFECT OF LHRH AGONIST ON TESTICULAR 17-HYDROXYLASE AND 5α-REDUCTASE ACTIVITIES IN NON-HYPOPHYSECTOMIZED ADULT RATS TREATED WITH AN ANTI-LUTEINIZING HORMONE SERUM
Carmichael, Rejean,Belanger, Alain
, p. 1 - 12 (2007/10/02)
In order to study both direct and pituitary-mediated mechanisms of action of the LHRH analogue 6, des-Gly-NH210>LHRH ethylamide upon testicular steroidogenesis in adult rat, we compared the effects of the agonist when administered alone or concomitantly with an anti-LH serum to non-hypophysectomized rats.Testicular steroid contents and in vitro progesterone and testosterone metabolism were determined.Anti-LH serum administration was able to prevent 5α-reductase stimulation by the agonistic peptide, but not the inhibition of 17-hydroxylase activity.These data suggest that modulation of 17-hydroxylase involves both direct and pituitary-mediated processes, while 5α-reductase stimulation is mainly if not only due to a pituitary-mediated mechanism.
