6890-65-9

Basic information

• Product Name: 5-ALPHA-PREGNAN-3-ALPHA, 17-DIOL-20-ONE
• Synonyms: 5-ALPHA-PREGNAN-3-ALPHA, 17-DIOL-20-ONE;5ALPHA-PREGNAN-3ALPHA,17ALPHA-DIOL-20-ONE;3alpha,17-dihydroxy-5alpha-pregnan-20-one
• CAS NO: 6890-65-9
• Molecular Formula: C₂₁H₃₄O₃
• Molecular Weight: 334.49
• EINECS: 229-994-6
• Mol File: 6890-65-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-ALPHA-PREGNAN-3-ALPHA, 17-DIOL-20-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ALPHA-PREGNAN-3-ALPHA, 17-DIOL-20-ONE(6890-65-9)
• EPA Substance Registry System: 5-ALPHA-PREGNAN-3-ALPHA, 17-DIOL-20-ONE(6890-65-9)

Safety Data

• Hazardous Substances Data: 6890-65-9(Hazardous Substances Data)

Usage

Uses

(3α,5α)-3,17-Dihydroxypregnan-20-one has been studied has a metabolite of research interest in the study of human male testes diseases or aberration pertaining androgen-mediated events in male puberty; such as biosynthesis of testosterone, adrenocortical carcinoma, castration-resistant prostate cancer and urine steroid hormone profiling.

Upstream product

• 74015-78-4 16α,17-epoxy-3α-hydroxy-5α-pregnan-20-one 
• 57-83-0 Progesterone 

Downstream Products

• 13933-75-0 5α-pregnane-3α,20α-diol 

Relevant articles and documents

STUDY OF THE DIRECT EFFECT OF LHRH AGONIST ON TESTICULAR 17-HYDROXYLASE AND 5α-REDUCTASE ACTIVITIES IN NON-HYPOPHYSECTOMIZED ADULT RATS TREATED WITH AN ANTI-LUTEINIZING HORMONE SERUM

In order to study both direct and pituitary-mediated mechanisms of action of the LHRH analogue 6, des-Gly-NH210>LHRH ethylamide upon testicular steroidogenesis in adult rat, we compared the effects of the agonist when administered alone or concomitantly with an anti-LH serum to non-hypophysectomized rats.Testicular steroid contents and in vitro progesterone and testosterone metabolism were determined.Anti-LH serum administration was able to prevent 5α-reductase stimulation by the agonistic peptide, but not the inhibition of 17-hydroxylase activity.These data suggest that modulation of 17-hydroxylase involves both direct and pituitary-mediated processes, while 5α-reductase stimulation is mainly if not only due to a pituitary-mediated mechanism.