68906-00-3

Upstream product

• 110-86-1 pyridine 
• 1670-14-0 benzamidine monohydrochloride 
• 34461-00-2 nitromalondialdehyde sodium salt 
• 14080-32-1 5-nitropyrimidine 
• 618-39-3 benzamidin 

Downstream Products

• 84928-86-9 2-phenyl-4-amino-5-nitropyrimidine 
• 21203-68-9 2-methyl-5-nitropyridine 
• 3665-80-3 N-Ethyl-4-nitroanilin 
• 100-23-2 N,N-Dimethyl-4-nitroaniline 
• 58259-34-0 N-butyl-4-nitroaniline 
• 4138-37-8 N-(sec-butyl)-4-nitroaniline 
• 100-15-2 N-methyl(p-nitroaniline) 
• 6960-20-9 3-methyl-5-nitropyridine 
• 77232-48-5 5-methyl-2-(phenyl)pyrimidine 
• 21164-35-2 2-phenyl-pyrimidine-4,5-diamine 
• 59808-52-5 5-amino-2-phenylpyrimidine 
• 17802-53-8 N-(2-phenylpyrimidin-5-yl)acetamide 

Relevant academic research and scientific papers

Synthesis, Characterization, and Rapid Cycloadditions of 5-Nitro-1,2,3-triazine

The synthesis, characterization, and a study of the cycloaddition reactions of 5-nitro-1,2,3-triazine (3) are reported. The electron-deficient nature of 3 permits rapid cycloaddition with a variety of electron-rich dienophiles, including amidines, enamines, enol ethers, ynamines, and ketene acetals in high to moderate yields. 1H NMR studies of a representative cycloaddition reaction between 3 and an amidine revealed a remarkable reaction rate and efficiency (1 mM, 3CN, 23 °C, >95%).

NOVEL BENZIMIDAZOLE DERIVATIVES

A compound of the formula (I): (wherein A, B, C and D are independently nitrogen or optionally substituted methine; E is nitrogen, methine or hydroxy substituted methine; n is 0 or 1; T, U, V and W are independently nitrogen or optionally substituted methine; X is -N(S02R4)-, - N (COR5) - or -CO-; Y is -C (R6) (R7)_,-0- or -N (R8)_, provided that the compound (I) when E is nitrogen, n is 0, X is -CO-, and Y is -0- is excluded) is useful as an agent for the treatment of various diseases related to NPY, for example cardiovascular disorders such as angina, acute or congestive heart failure, myocardial infarction, hypertension, nephropathy, electrolyte abnormality, vasospasm, arteriosclerosis, etc., central nervous system disorders such as bulimia, depression, anxiety, seizure, epilepsy, dementia, pain, alcoholism, drug withdrawal, circadian rhythm disorders, schizophrenia, memory impairment, sleep disorders, cognitive impairment, etc., metabolic diseases such as obesity, diabetes, hormone abnormality, hypercholesterolemia, hyperlipidemia, gout, fatty liver, etc., genital or reproductive disorders such as infertility, preterm labor, sexual dysfunction, etc., gastro-intestinal disorders, respiratory disorder, inflammatory diseases or glaucoma, and the like, also for example, atherosclerosis, hypogonadism, hyperandrogenism, polycystic ovary syndrome, hirsutism, gastro-intestinal motility disorder, obesity-related gastro-esophageal reflux, obesity hypoventilation (Pickwickian syndrome), sleep apnea, inflammation, systemic inflammation of the vasculature, osteoarthritis, insulin resistance, bronchoconstriction, alcohol preference, metabolic syndrome, Alzheimer's disease, cardiac hypertrophy, left ventricular hypertrophy, hypertriglyceridemia, low HDL cholesterol, cardiovascular disorders such as coronary heart disease (CHD), cerebrovascular disease, stroke, peripheral vascular disease, sudden death, gallbladder diseases, cancer (breast, endometrial, colon), breathlessness, hyperuricemia, impaired fertility, low back pain, and increased anesthetic risk.

Ring Transformations in Reactions of Heterocyclic Compounds with Nucleophiles. Conversion of 5-Nitropyrimidine into 2-Substituted 5-Nitropyrimidine and 2-Amino-5-nitropyridines by Amidines

The reaction of 5-nitropyrimidine (1) with benzamidine, pivalamidine, acetamidine, propionamidine, α-phenylacetamidine, O-methylisourea hydrochlorides, and cyanamide in ethanolic solution in the presence of triethylamine has been investigated.It was found that reaction of 1 with alkyl(aryl) amidines, having no active methylene groups attached to the amidine moiety (pivalamidine, benzamidine), exclusively formed the corresponding 2-substituted 5-nitropyrimidines in good yields.With acetamidine and propionamidine, in addition to the formation of the 2-substituted 5-nitropyrimidines, the formation of 2-amino-5-nitropyridines also was observed; with α-phenylacetamidine a 2-amino-5-nitropyridine derivative exclusively was obtained.The reaction of 1 with both O-methylisourea and cyanamide leads to 2-amino-5-nitropyrimidine.These reactions provide new examples of degenerate ring transformations of the pyrimidine ring system and of the ring transformation of pyrimidines into pyridines.