68907-48-2

Upstream product

• 75-15-0 carbon disulfide 
• 130061-59-5 Methyl 4,6-O-benzylidene-2-deoxy-2-methyl-α-D-glucopyranoside 
• 74-88-4 methyl iodide 
• 68907-47-1 methyl 4,6-O-benzylidene-2-deoxy-2-C-methyl-α-D-altro-pyranoside 

Downstream Products

• 68880-90-0 methyl 4,6-O-benzylidene-2,3-dideoxy-2-C-methyl-α-D-arabino-hexopyranoside 
• 68880-94-4 methyl 2,3,4-trideoxy-2-C-methyl-6-O-triphenylmethyl-α-D-threo-hexopyranoside 
• 79646-64-3 methyl 2,3,4-trideoxy-2,4-di-C-methyl-α-D-arabino-hexopyranoside 
• 68880-95-5 methyl 2,3,4-trideoxy-2,4-di-C-methyl-6-O-(triphenylmethyl)-α-D-lyxo-hexopyranoside 
• 68880-92-2 methyl 2,3-dideoxy-2-C-methyl-6-O-(triphenylmethyl)-α-D-arabino-hexopyranoside 
• 59014-03-8 (-)-α-multistriatin 
• 68880-93-3 methyl 2,3-dideoxy-2-C-methyl-6-O-triphenylmethyl-α-D-threo-hexopyranosid-4-ulose 
• 457623-06-2 1-((2S,6S)-6-Methoxy-5-methyl-3,6-dihydro-2H-pyran-2-yl)-ethanone 
• 189453-10-9 epothilone D 
• 152044-54-7 epothilone B 
• 56981-06-7 (2R,4aR,6S,8aS)-6-Methoxy-7-methyl-2-phenyl-4,4a,6,8a-tetrahydro-pyrano[3,2-d][1,3]dioxine 
• 129991-98-6 (2S,3R,5S,6R)-2,5-Dimethoxy-3-methyl-6-trityloxymethyl-tetrahydro-pyran 
• 68880-92-2 (2R,3S,5R,6S)-6-Methoxy-5-methyl-2-trityloxymethyl-tetrahydro-pyran-3-ol 
• 105930-42-5 (2R,4aR,6S,7R,8aS)-6-Methoxy-7-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine 

Relevant academic research and scientific papers

Synthesis of epothilones B and D from D-glucose

An enantiospecific total synthesis of epothilones B and D from D-glucose is reported.

Studies directed towards the synthesis of immunosuppressive agent FK-506: Construction of the tricarbonyl moiety

Alkylation of a suitably functionalised dithiane precursor with L-N-(α-haloacetyl)-pipecolic acid methyl ester, followed by oxidation of the active methylene group provided an easy route to 1,2,3-tricarbonyl functionality of FK-506.