191538-87-1

Upstream product

• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 532-20-7 D-xylofuranose 
• 6893-67-0 1,2-O-isopropylidene-3,5-di-O-benzoyl-α-D-xylofuranose 
• 191538-37-1 3,5-di-O-benzoyl-α-D-xylo-furanose 1,2-thiocarbonate 

Downstream Products

• 196867-36-4 C₂₃H₂₀IN₃O₆ 
• 196867-33-1 C₂₃H₁₉IN₂O₇ 
• 196867-32-0 1-(3',5'-di-O-benzoyl-2'-deoxy-2'-iodo-β-D-xylopentofuranosyl)thymine 
• 196867-34-2 C₂₃H₁₈FIN₂O₇ 
• 219989-63-6 C₂₃H₁₉FIN₃O₆ 
• 14486-22-7 1-(2,3-anhydro-β-D-lyxofuranosyl)thymine 
• 70838-47-0 (2R,3R,5R)-2-(benzoyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-3-yl benzoate 
• 16053-52-4 threothymidine 
• 134379-77-4 β-D-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine 
• 219989-60-3 Benzoic acid (2S,5R)-5-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl ester 

Relevant academic research and scientific papers

Synthesis and comparative evaluation of two antiviral agents: β-L- Fd4C and β-D-Fd4C

The synthesis of β-D-Fd4C was achieved in a stereoselective fashion from D-xylose. The antiviral activity and cytotoxicity of β-D-Fd4C was compared with that of β-L-Fd4C and 3TC (Lamivudine). Of the three agents compared, β-L-Fd4C was found to be the most potent antiviral agent.

Synthesis of furanose glycals from furanose 1,2-diols and their cyclic thiocarbonate esters

Two new methods for the synthesis of furanoid glycals are described. Both procedures were shown to be faster and cheaper that those previously reported. Protected 1,2-dihydroxypento- and hexo-furanose derivatives with the D-xylo, D-gluco and D-ribo, D-all

An efficient and highly stereoselective synthesis of nucleoside derivatives from furanoid 1,2-diols

Reaction between suitably protected furanoid glycals 1b-4b, readily obtained from furanoid 1,2-diols (1a-4a), and different silylated pyrimidine bases, gave the corresponding 3',5'- and 3',5',6'-O-protected 2'-deoxy-2'-iodo-β-D-xylo-pentofuranosyl 5-10 and β-D-gluco-hexofuranosyl 11 nucleosides, respectively. Compound 5 has been transformed into its 2'-deoxy 12 and 2',3'-anhydro 14 derivatives. The high stereoselectivity of the reaction is discussed.