68960-97-4

Usage

Uses

Used in Bioconjugation:
1,14-diamino-3,6,9,12-tetraoxatetradecane is used as a crosslinker in bioconjugation for the formation of stable covalent bonds between biomolecules, such as proteins, peptides, and nucleic acids. Its reactivity with various functional groups allows for the efficient and specific attachment of these biomolecules.
Used in Drug Delivery:
1,14-diamino-3,6,9,12-tetraoxatetradecane is used as a crosslinker in drug delivery systems for the development of targeted and controlled release formulations. Its ability to form stable covalent bonds with drug molecules and other components enables the design of drug delivery systems with improved stability, bioavailability, and therapeutic efficacy.
Used in PEG Hydrogel:
1,14-diamino-3,6,9,12-tetraoxatetradecane is used as a crosslinking agent in the synthesis of PEG hydrogels. These hydrogels have a wide range of applications in tissue engineering, drug delivery, and wound healing due to their biocompatibility, tunable mechanical properties, and ability to encapsulate bioactive molecules.
Used in Surface Functionalization:
1,14-diamino-3,6,9,12-tetraoxatetradecane is used as a crosslinker for surface functionalization in various applications, such as the modification of sensor surfaces, immobilization of enzymes, and the development of antimicrobial coatings. Its reactivity with different surface materials and functional groups allows for the creation of tailored surfaces with specific properties and functions.

Upstream product

• 70110-27-9 2,2'-(3,6,9,12-tetraoxatetradecane-1,14-diyl)bis(isoindoline-1,3-dione) 
• 5197-65-9 1,14-dichloro-3,6,9,12-tetraoxatetradecane 
• 4792-15-8 Pentaethylene glycol 
• 109789-39-1 pentaethylene glycol dimesylate 
• 182760-73-2 1,14-diazido-3,6,9,12-tetraoxatetradecane 

Downstream Products

• 1449685-16-8 C₄₄H₆₀N₈O₈ 
• 811442-84-9 tert-butyl N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate 
• 1426686-02-3 N,N'-(3,6,9,12-tetraoxatetradecane-1,14-diyl)bis(5-(3,5-dimethylisoxazol-4-yl)-2-methylbenzenesulfonamide) 
• 143029-11-2 (14R,15R)-14,15-Diphenyl-1,4,7,10-tetraoxa-13,16-diaza-cyclooctadecane 
• 143062-16-2 (14S,15R)-14,15-Diphenyl-1,4,7,10-tetraoxa-13,16-diaza-cyclooctadecane 
• 143029-07-6 [1-Phenyl-meth-(E)-ylidene]-[2-(2-{2-[2-(2-{[1-phenyl-meth-(E)-ylidene]-amino}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethyl]-amine 
• 111039-21-5 1,9,12,15,18,26,29,32-Octaoxa-4,6,21,23-tetraaza-cyclotetratriacontane-5,22-dithione 

Relevant academic research and scientific papers

PEGylated atorvastatin derivative and preparation method thereof

The invention relates to a PEGylated atorvastatin derivative and a preparation method thereof. The method mainly comprises the following steps: 1) activating an end group of PEG; 2) enabling the activated PEG to react with atorvastatin to obtain an atorvastatin analogue. The structure of the atorvastatin analogue is: Atorvastatin-L-PEG-L-Atorvastatin, wherein Atorvastatin is atorvastatin; L is anester bond, an amido bond or other linking group; the PEG is residue of monodisperse polyethylene glycol; the structural formula of the atorvastatin analogue is shown in the description, where n is aninteger between 1 and 24. The preparation method has the advantages of short flow, easiness and convenience in reaction operation, few side reactions, low cost, high reaction selectivity, easiness inpurification and higher yield.

Polyacrylamide pseudo crown ethers via hydrogen bond-assisted cyclopolymerization

Polyacrylamide pseudo crown ethers with large in-chain rings (15–24 membered) were synthesized by hydrogen bond-mediated cyclopolymerization of bisacrylamides comprising poly(ethylene oxide) spacers (PEGnDAAm, ethylene oxide units: n = 3–6). The monomers undergo the intramolecular hydrogen bonding of the bisacrylamide units in halogenated solvents to dynamically place the two olefins adjacently. As a result, the bisacrylamides homogeneously allowed controlled radical cyclopolymerization without any macroscopic gelation in 1,2-dichloroethane, even at relatively high concentration of monomers (200 mM), to directly provide precision cyclopolyacrylamides and the related copolymers with high cyclization efficiency (84–98%). Owing to the in-chain ring pendants, a cyclopolyacrylamide had glass transition temperature higher than a corresponding polyacrylamide with linear pendants.

Optimization of the Sensitization Process and Stability of Octadentate Eu(III) 1,2-HOPO Complexes

The synthesis of a series of octadentate ligands containing the 1-hydroxypyridin-2-one (1,2-HOPO) group in complex with europium(III) is reported. Within this series, the central bridge connecting two diethylenetriamine units linked to two 1,2-HOPO chromophores at the extremities (5-LIN-1,2-HOPO) is varied from a short ethylene chain (H(2,2)-1,2-HOPO) to a long pentaethylene oxide chain (H(17O5,2)-1,2-HOPO). The thermodynamic stability of the europium complexes has been studied and reveals these complexes may be effective for biological measurements. Extension of the central bridge results in exclusion of the inner-sphere water molecule observed for [Eu(H(2,2)-1,2-HOPO)]- going from a nonacoordinated to an octacoordinated Eu(III) ion. With the longer chain length ligands, the complexes display increased luminescence properties in aqueous medium with an optimum of 20% luminescence quantum yield for the [Eu(H(17O5,2)-1,2-HOPO)]- complex. The luminescence properties for [Eu(H(14O4,2)-1,2-HOPO)]- and [Eu(H(17O5,2)-1,2-HOPO)]- are better than that of the model bis-tetradentate [Eu(5LINMe-1,2-HOPO)2]- complex, suggesting a different geometry around the metal center despite the geometric freedom allowed by the longer central chain in the H(mOn,2) scaffold. These differences are also evidenced by examining the luminescence spectra at room temperature and at 77 K and by calculating the luminescence kinetic parameters of the europium complexes. (Graph Presented).

Preparation and characterization of an improved Cu2+-cyclen polyurethane material that catalyzes generation of nitric oxide from S-nitrosothiols

A new, stable and highly efficient Cu2+-cyclen-polyurethane material is described and shown to exhibit an improved performance compared to that of prior materials for the catalytic decomposition of S-nitrosothiols to physiologically active nitric oxide. The Royal Society of Chemistry.

Catalysis in Aprotic Solvents. Inter- and Intramolecular Hydrogen Bonding Complexation

A mechanistic investigation is reported of aminolysis reactions of 2-hydroxy-5-nitro-α-toluenesulfonic acid sultone (1) in aprotic solvents.The n-butylaminolysis of 1 in acetonitrile and in toluene requires two and three molecules of amine, respectively.In the latter solvent, general bases strongly catalyze the reaction, and their catalytic constants are well correlated by the hydrogen bonding parameter pKHB.These results are interpreted by a multistep mechanism where each intermediate can be stabilized via hydrogen bonding by general bases.The mechanistic features depend on the stability of the intermediates and on the solvent characteristics.When diamines such as polyoxyethylenediamines H2NCH2(CH2OCH2)nCH2NH2 (2, n=2; 3, n=4; 4, n=6) are used as nucleophiles for the reaction with sultone 1 in toluene, much higher reactivities are observed when compared to reactions of monoamines and alkylenediamines.This represents a novel type of intramolecular catalysis due to intramolecular hydrogen bonding complexation between oxygen atoms and the ammonium group of the reaction intermediates (Scheme III).In toluene 2-4 also display a large basicity.