68963-39-3Relevant academic research and scientific papers
A new and direct approach to functionalized biaryl α-ketophosphonic acids via aqueous Suzuki coupling on solid support
Li, Xianfeng,Szardenings, Anna Katrin,Holmes, Christopher P.,Wang, Liang,Bhandari, Ashok,Shi, Lihong,Navre, Marc,Jang, Larry,Grove, J. Russell
, p. 19 - 22 (2006)
A new method for the synthesis of functionalized biaryl α-ketophosphonic acids has been developed. The key step involves the use of sodium bromobenzoyl phosphonates to react with polymer-bound boronic acids via microwave-assisted aqueous Suzuki coupling. This approach provides rapid access to a wide range of diverse biaryl analogues containing an α-ketophosphonic acid moiety.
