69015-75-4

Usage

Uses

Used in Organic Synthesis:
(4Z)-2-phenyl-4-(1-phenylethylidene)-1,3-oxazol-5(4H)-one is used as a building block in organic synthesis for its ability to form more complex molecules. Its unique structure allows for the creation of a wide range of chemical compounds, making it a versatile component in the synthesis process.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (4Z)-2-phenyl-4-(1-phenylethylidene)-1,3-oxazol-5(4H)-one is used as a key component in the development of pharmaceutical compounds. Its structural properties make it a promising candidate for the creation of new drugs with potential therapeutic benefits.
Used in Drug Discovery:
The potential biological activity of (4Z)-2-phenyl-4-(1-phenylethylidene)-1,3-oxazol-5(4H)-one makes it a valuable compound in drug discovery. Researchers can explore its properties to identify possible therapeutic applications and develop new treatments for various medical conditions.
Used in Pharmaceutical Industry:
Within the pharmaceutical industry, (4Z)-2-phenyl-4-(1-phenylethylidene)-1,3-oxazol-5(4H)-one is used as a starting material for the synthesis of various drugs. Its versatility and potential for creating complex molecules contribute to its importance in the development of new medications.

Upstream product

• 495-69-2 Hippuric Acid 
• 98-86-2 acetophenone 
• 186581-53-3 diazomethane 
• 17606-70-1 (4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one 
• 15732-43-1 (E)-2-phenyl-4-benzylidene-5(4H)-oxazolone 
• 1199-01-5 2-phenylazlactone 
• 5447-87-0 2-(1-phenylethylidene)propanedinitrile 

Downstream Products

• 89141-16-2 (Z)-N-benzoyl-β-methyldidehydrophenylalanine methyl ester 
• 118251-78-8 (+)-<(Z)-N-benzoyl-β-methyldidehydrophenylalanyl>-L-phenylalanine 
• 77381-30-7 (Z)-2-Benzoylamino-3-phenyl-but-2-enoic acid 
• 84405-00-5 N-((Z)-1-Cyclohexylcarbamoyl-2-phenyl-propenyl)-benzamide 
• 84404-88-6 N-[(Z)-1-(4-Methoxy-phenylcarbamoyl)-2-phenyl-propenyl]-benzamide 
• 1618107-17-7 (R)-N-(1-ethyl-2,6'-dioxo-4'-phenyl-3',6'-dihydrospiro[indoline-3,2'-pyran]-5'-yl)benzamide 
• 1618107-18-8 (R)-N-(5-bromo-1-ethyl-2,6'-dioxo-4'-phenyl-3',6'-dihydrospiro[indoline-3,2'-pyran]-5'-yl)benzamide 
• 1618107-19-9 (R)-N-(6-bromo-1-ethyl-2,6'-dioxo-4'-phenyl-3',6'-dihydrospiro[indoline-3,2'-pyran]-5'-yl)benzamide 
• 1618107-21-3 (R)-N-(1-ethyl-5-methyl-2,6'-dioxo-4'-phenyl-3',6'-dihydrospiro[indoline-3,2'-pyran]-5'-yl)benzamide 
• 1618107-22-4 (R)-N-(1-ethyl-7-methyl-2,6'-dioxo-4'-phenyl-3',6'-dihydrospiro[indoline-3,2'-pyran]-5'-yl)benzamide 
• 1618107-23-5 (R)-N-(1-ethyl-5,7-dimethyl-2,6'-dioxo-4'-phenyl-3',6'-dihydrospiro[indoline-3,2'-pyran]-5'-yl)benzamide 
• 1618107-24-6 (R)-N-(5-chloro-1-ethyl-2,6'-dioxo-4'-phenyl-3',6'-dihydrospiro[indoline-3,2'-pyran]-5'-yl)benzamide 
• 1618107-25-7 (R)-N-(6-chloro-1-ethyl-2,6'-dioxo-4'-phenyl-3',6'-dihydrospiro[indoline-3,2'-pyran]-5'-yl)benzamide 
• 1618107-26-8 (R)-N-(1-ethyl-5-fluoro-2,6'-dioxo-4'-phenyl-3',6'-dihydrospiro[indoline-3,2'-pyran]-5'-yl)benzamide 

Relevant academic research and scientific papers

DUAL EMISSION FLUORESCENT COMPOUNDS

The invention relates to a dual emission fluorescent compound comprising a chromophore suitable for exhibiting an emission at a first wavelength from an excited state; wherein the compound further comprises one or more groups suitable for inducing a structural rearrangement in the molecule on formation of the excited state, wherein the structural rearrangement stabilises at least a second electromagnetic emission at a second wavelength, such that dual emission is observable at room temperature. Such dual emission allows for the super sensitive ratiometric quantification of analytes.

A catalytic asymmetric hetero-Diels-Alder reaction of olefinic azlactones and isatins: Facile access to chiral spirooxindole dihydropyranones

A catalytic asymmetric hetero-Diels-Alder (HDA) reaction has been achieved through hydrogen-bond directed γ-addition of olefinic azlactones to isatins. This methodology provides an efficient access to spirooxindole dihydropyranones in moderate to good yie

Novel synthesis of unsaturated 5(4H)-oxazolone derivatives with using palladium(II) acetate as a catalyst and microvawe irradiation in solvent-free condition

Unsaturated 5(4H)-oxazolones have emerged as an important class of synthons. These compounds have prepared with using palladium(II) acetate under free-solvent conditions with excellent yields and microwave irradiation.

An efficient and stereodivergent synthesis of threo- and erythro-β-methylphenylalanine. Resolution of each racemic pair by semipreparative HPLC

threo and erythro diastereoisomers of the constrained amino acid (βMe)Phe can be obtained separately on a multigram scale through a three-step synthesis from the corresponding Z and E isomers of 2-phenyl-4(α-phenylethylidene)-5(4H)-oxazolone. The 5(4H)-ox

On the Synthesis of Geometric Isomers of 2-Methyl (or Phenyl)-4--5(4H)-oxazolones

Several Z-2-methyl(or phenyl)-4--5(4H)-oxazolones 3Z, 4Z were prepared.The results obtained were compared by diazomethane insertion and condensation procedure.In order to synthetize E-2-phenyl-4--5-(4H)-oxazolones 4E hy

Reaction of 4-Methylene-5(4H)-oxazolones With Diazomethane

The reaction of diazomethane with some (E) and (Z)-2-substituted-4-methylene-5(4)-oxazolones (1a-c) under two different conditions, has been studied. (E) and (Z)-1,2-disubstituted-7-oxo-6-oxa-4-azaspiro-hept-4-enes (3a-c, 4a-c) were mainly obtained, together with multiple addition compounds.The reaction showed to be stereoselective only when the substituents were aromatic.Acid hydrolysis of compounds 3a and 4a produced a mixture of (E) and (Z)-3,5-disubstituted-tetrahydrofuran-2-ones (8a, 9a).Smooth methanolysis of the ring led to (E) and (Z)-1-benzamido-cyclopropanecarboxylic esters (10a-c, 11a-c), which, on acid hydrolysis, gave (E) and (Z)-1-amino-2-phenylcyclopropanecarboxylic acids 12a and 13a.The pmr spectra have been analyzed by an iterative computer method, and the computed best values obtained have been used to deduce the stereochemistry of the spiroderivatives.