690265-92-0

Basic information

• Product Name: 1-[3-(4-bromophenylprop-2-ynyl)]pyrrolidine
• Synonyms: 1-[3-(4-bromophenylprop-2-ynyl)]pyrrolidine
• CAS NO: 690265-92-0
• Molecular Weight: 264.165
• Mol File: 690265-92-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-[3-(4-bromophenylprop-2-ynyl)]pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3-(4-bromophenylprop-2-ynyl)]pyrrolidine(690265-92-0)
• EPA Substance Registry System: 1-[3-(4-bromophenylprop-2-ynyl)]pyrrolidine(690265-92-0)

Safety Data

• Hazardous Substances Data: 690265-92-0(Hazardous Substances Data)

Upstream product

• 7223-42-9 1-(prop-2-yn-1-yl)pyrrolidine 
• 589-87-7 1,4-bromoiodobenzene 
• 50-00-0 formaldehyd 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 16596-41-1 N-aminopyrrolidine 
• 27793-68-6 decahydro-2,6-naphthalenedione monoethylene ketal 
• 352-34-1 4-fluoro-1-iodobenzene 
• 529-28-2 4-iodoanisol 
• 624-31-7 4-tolyl iodide 
• 696-62-8 para-iodoanisole 
• 231295-19-5 6-chloro-N-methoxy-N-methyl-1H-indole-2-carboxamide 
• 147223-00-5 2,3-Difluoro-4-n-nonoxyphenylboronic acid 
• 123-75-1 pyrrolidine 
• 75-09-2 dichloromethane 

Downstream Products

• 690265-93-1 1-[3-(4-iodo-phenyl)-prop-2-inyl]-pyrrolidine 

Relevant articles and documents

Synthesis of 6-Bromo-3a,4-dihydrobenzo[f]isoindolinium Bromides and Their Aqueous-Alkaline Cleavage

Cyclization of allyl[3-(4-bromophenyl)prop-2-ynyl]ammonium bromides under basic catalysis conditions, unlike their propargyl analogs, occurs under heating of the reaction mixture at 90–92°C. Cyclization, which is the main reaction route, is accompanied by

Simplifying the conductance profiles of molecular junctions: The use of the trimethylsilylethynyl moiety as a molecule-gold contact

Conductance across a metal|molecule|metal junction is strongly influenced by the molecule-substrate contacts, and for a given molecular structure, multiple conductance values are frequently observed and ascribed to distinct binding modes of the contact at each of the molecular termini. Conjugated molecules containing a trimethylsilylethynyl terminus, -C≡CSiMe 3 give exclusively a single conductance value in I(s) measurements on gold substrates, the value of which is similar to that observed for the same molecular backbone with thiol and amine based contacting groups when bound to under-coordinated surface sites.

Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds

The present invention relates to alkyne compounds of general formula I wherein the groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. The invention further relates to pharmaceutical compositions containing at least one alkyne according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.