690635-63-3

Upstream product

• 1011-40-1 2-phenyl-1,3-thiazole-5-carbaldehyde 
• 2227-79-4 benzenecarbothioamide 

Downstream Products

• 690635-64-4 7-bromo-2-phenyl[1,3]thiazolo[4,5-c]pyridin-4(5H)-one 
• 690635-65-5 4-chloro-2-phenyl[1,3]thiazolo[4,5-c]pyridine-7-carbonitrile 
• 690635-66-6 4-oxo-2-phenyl-4,5-dihydro-thiazolo[4,5-c]pyridine-7-carbonitrile 
• 912369-14-3 tert-butyl (3S)-3-[(7-cyano-2-phenyl[1,3]thiazolo[4,5-c]pyridin-4-yl)amino]piperidine-1-carboxylate 

Relevant academic research and scientific papers

SUBSTITUTED HETEROCYCLES AND THEIR USE AS CHK1, PDK1 AND PAK INHIBITORS

This invention relates to novel compounds of Formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds possess CHK1 kinase inhibitory activity, PDK1 inhibitory activity and Pak kinase inhibitory activity and are accordingly useful in the treatment and/or prophylaxis of cancer.

Antiinflammation agents

Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.