1011-40-1

Basic information

• Product Name: 2-PHENYL-1,3-THIAZOLE-5-CARBALDEHYDE
• Synonyms: 2-PHENYL-THIAZOLE-5-CARBALDEHYDE;2-PHENYL-1,3-THIAZOLE-5-CARBALDEHYDE;CHEMBRDG-BB 4301192;2-PHENYLTHIAZOLE-5-CARBALDEHYDE, 95+%;2-phenyl-1,3-thiazole-5-carbaldehyde(SALTDATA: FREE);2-Phenyl-5-forMylthiazole;2-Phenylthiazole-5-carboxaldehyde;5-Thiazolecarboxaldehyde,2-phenyl-
• CAS NO: 1011-40-1
• Molecular Formula: C₁₀H₇NOS
• Molecular Weight: 189.23
• Product Categories: API intermediates
• Mol File: 1011-40-1.mol

Chemical Properties

• Melting Point: 78-80°C
• Boiling Point: 352.977 °C at 760 mmHg
• Flash Point: 167.275 °C
• Appearance: /
• Density: 1.269 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.645
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.65±0.10(Predicted)
• CAS DataBase Reference: 2-PHENYL-1,3-THIAZOLE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-1,3-THIAZOLE-5-CARBALDEHYDE(1011-40-1)
• EPA Substance Registry System: 2-PHENYL-1,3-THIAZOLE-5-CARBALDEHYDE(1011-40-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 1011-40-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-Phenyl-1,3-thiazole-5-carbaldehyde is used as a building block in organic synthesis for its aromatic and thiazole ring, which allows for a wide range of chemical reactions and the creation of diverse chemical compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-Phenyl-1,3-thiazole-5-carbaldehyde is used as a key intermediate in the synthesis of various drugs, leveraging its unique structural features to develop new medicinal compounds.
Used in Agrochemical Production:
2-Phenyl-1,3-thiazole-5-carbaldehyde is employed in the development of agrochemicals, where its chemical properties contribute to the creation of effective products for agricultural applications.
Used in Materials Science:
In materials science, 2-Phenyl-1,3-thiazole-5-carbaldehyde is utilized for its potential to enhance the properties of various materials, such as improving their stability, reactivity, or other characteristics.
Used in Medicine and Drug Discovery:
Due to its unique structural features, 2-Phenyl-1,3-thiazole-5-carbaldehyde is used in the field of medicine and drug discovery, where it may contribute to the development of new therapeutic agents.
Used as a Reagent in Chemical Research:
2-Phenyl-1,3-thiazole-5-carbaldehyde serves as a reagent in chemical research, where it is employed in various experiments and studies to explore its properties and potential applications.

InChI:InChI=1/C10H7NOS/c12-7-9-6-11-10(13-9)8-4-2-1-3-5-8/h1-7H

Upstream product

• 859485-91-9 5-hydroxymethyl-2-phenylthiazole 
• 172678-67-0 ethyl 2-phenyl-1,3-thiazole-5-carboxylate 
• 98-80-6 phenylboronic acid 
• 464192-28-7 2-bromo-1,3-thiazole-5-carbaldehyde 
• 36437-19-1 2-chloromalonaldehyde 
• 2227-79-4 benzenecarbothioamide 

Downstream Products

• 946501-52-6 2,2,2-trifluoro-1-(2-phenyl-1,3-thiazol-5-yl)ethanol 
• 1195985-33-1 (R)-1-phenyl-N-((2-phenyl-1,3-thiazol-5-yl)methyl)ethanamine 
• 1826-11-5 2-phenylthiazole 
• 859485-91-9 5-hydroxymethyl-2-phenylthiazole 
• 912369-14-3 tert-butyl (3S)-3-[(7-cyano-2-phenyl[1,3]thiazolo[4,5-c]pyridin-4-yl)amino]piperidine-1-carboxylate 
• 690635-66-6 4-oxo-2-phenyl-4,5-dihydro-thiazolo[4,5-c]pyridine-7-carbonitrile 
• 690635-65-5 4-chloro-2-phenyl[1,3]thiazolo[4,5-c]pyridine-7-carbonitrile 
• 690635-64-4 7-bromo-2-phenyl[1,3]thiazolo[4,5-c]pyridin-4(5H)-one 
• 690635-63-3 2-phenyl[1,3]thiazolo[4,5-c]pyridin-4(5H)-one 
• 1311195-97-7 (2-phenylthiazol-5-yl)(3,4,5-trimethoxyphenyl)methanol 
• 1311195-65-9 (2-phenylthiazol-5-yl)(3,4,5-trimethoxyphenyl)methanone 
• 1235472-05-5 4-amino-5-cyano-6-ethoxy-N-((1-((2-phenylthiazol-5-yl)methyl)piperidin-4-yl)methyl)picolinamide 
• 787548-92-9 3-(2-phenyl-thiazol-5-yl)-4-{2-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-propyl]-thiazol-4-yl}-butyric acid ethyl ester 
• 722549-34-0 ethyl 6-chloro-5-oxo-3-(2-phenyl-1,3-thiazol-5-yl)hexanoate 

Relevant articles and documents

THIAZOLE CARBOXAMIDE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS

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Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcohols is reported. This reaction was highly efficient and tolerated various heteroaryl alcohols, generating a carboxylic acid derivative and a neutral heteroaromatic compound. Experimental studies combined with density functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.

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SUBSTITUTED HETEROCYCLES AND THEIR USE AS CHK1, PDK1 AND PAK INHIBITORS

This invention relates to novel compounds of Formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds possess CHK1 kinase inhibitory activity, PDK1 inhibitory activity and Pak kinase inhibitory activity and are accordingly useful in the treatment and/or prophylaxis of cancer.

Antiinflammation agents

Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.

Erythromycin derivatives

A compound selected from the group consisting of a compound of the formula STR1 wherein R1 and R2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 24 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of oxygen, sulfur and nitrogen and optionally having at least one functional group or taken together form STR2 and R'1 and R'2 are individually selected from the group consisting of hydrogen and an optionally unsaturated hydrocarbon of up to 23 carbon atoms optionally interrupted by at least one heteroatom selected from the group consisting of nitrogen, oxygen and sulfur and optionally having at least one functional group, Z is hydrogen or acyl of an organic carboxylic acid of 1 to 18 carbon atoms and the wavy line indicates the 10-methyl may have R or S configuration or a mixture of R+S and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic properties.