6907-70-6Relevant academic research and scientific papers
Efficient iodine catalyzed chemoselective synthesis of aminals - An access to N,N-acetals by the addition of lactams to N-acyl imines
Ramachandran, Gunasekar,Sathiyanarayanan, Kulathu I.
supporting information, p. 6758 - 6763 (2013/11/19)
A highly efficient protocol has been developed for the synthesis of aminals from γ-butyrolactam and benzaldehyde using iodine as Lewis acid catalyst. The attack of γ-butyrolactam nucleophile to intermediate N-acyliminium ion was more favorable, when aryl
N-SUBSTITUTED DERIVATIVES OF 2-PYRROLIDONE IN THE SILYL METHOD OF C- AND N-AMIDOALKYLATION
Shipov, A. G.,Zheltonogova, E. A.,Kobzareva, V. P.,Orlova, N. A.,Baukov, Yu. I.
, p. 2142 - 2150 (2007/10/02)
With O-silyl-substituted enols and 1-trimethylsilyl-2-pyrrolidone in the presence of catalytic amounts of trimethylsilyl triflate under mild conditions the adducts of 1-trimethylsilyl-2-pyrrolidone with benzaldehyde and furfural form the products from C- and N-amidoalkylation respectively.The N- and C-amidoalkylation products containing an ethoxycarbonyl group at the electrophilic center can be obtained by the reaction of 1-(1-chloro-1-ethoxycarbonylmethyl)-2-pyrrolidone with the above-mentioned organosilicon nucleophiles.In the reaction of 2-pyrrolidone, ethyl glyoxalate, and dimethylchlorosilane in the presence of stannic chloride reductive alkylation of the 1-lactam acetic ester occurs.
