6907-73-9Relevant academic research and scientific papers
Montmorillonite as a heterogeneous catalyst in the efficient, mild and one pot synthesis of Schiff bases under solvent-free conditions
Naeimi, Hossein,Rabiei, Khadijeh
experimental part, p. 208 - 212 (2012/07/03)
A mild and efficient method has been reported for preparation of Schiff base ligands through condensation reaction of various aromatic aldehydes and ketones with different aromatic amines in the presence of montmorillonite as a heterogeneous catalyst under solvent free conditions. The advantages of this friendly, economically, environmentally and mild method are such as; simplicity of the reaction procedure, reusability of catalyst, simple work-up, high product yields and very short reaction times.
Synthesis and structure-activity relationship of disubstituted benzamides as a novel class of antimalarial agents
Mitachi, Katsuhiko,Salinas, Yandira G.,Connelly, Michele,Jensen, Nicholas,Ling, Taotao,Rivas, Fatima
supporting information; experimental part, p. 4536 - 4539 (2012/08/07)
Malaria is a devastating world health problem. Using a compound library screening approach, we identified a novel series of disubstituted benzamide compounds with significant activity against malaria strains 3D7 and K1. These compounds represent a new antimalarial molecular scaffold exemplified by compound 1, which demonstrated EC50 values of 60 and 430 nM against strains 3D7 and K1, respectively. Herein we report our findings on the efficient synthesis, structure-activity relationships, and biological activity of this new class of antimalarial agents.
Nucleophilic trifluoromethylation of imines under acidic conditions
Levin, Vitalij V.,Dilman, Alexander D.,Belyakov, Pavel A.,Struchkova, Marina I.,Tartakovsky, Vladimir A.
supporting information; experimental part, p. 5226 - 5230 (2009/06/06)
A general method for the trifluoromethylation of imines by using Me 3SiCF3 under acidic conditions is described. The reaction is promoted by hydrofluoric acid generated in situ from KHF2 and either TFA or TfOH. A new chemoselectivity pattern was achieved, as the C=N bond was found to be more reactivate than the carbonyl group. The trifluoromethylation reaction is believed to proceed by concerted transfer of the CF3 group from the silicon atom to the iminium electrophile. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
Facile and efficient method for preparation of Schiff bases catalyzed by P2O5/SiO2 under free Solvent conditions
Naeimi, Hossein,Sharghi, Hashem,Salimi, Fariba,Rabiei, Khadijeh
, p. 43 - 47 (2008/03/30)
A simple and convenient method for the preparation of Schiff bases is developed. In this method, the Schiff base compounds were prepared from the reaction of carbonyl compounds with primary amines. In this reaction, P 2O5/SiO2 have catalyzed the Schiff base formation in dry media under solvent-free conditions. Advantages of this method are use of an inexpensive and efficient catalyst, high yields of products, short reaction times, and simplicity of the reaction and workup.
New entries toward 3,3-difluoropiperidines
Verniest, Guido,Surmont, Riccardo,Van Hende, Eva,Deweweire, Arvid,Deroose, Frederik,Thuring, Jan Willem,De Kimpe, Norbert
, p. 5458 - 5461 (2008/12/21)
(Chemical Equation Presented) Difluoropiperidines attract considerable interest from organic and medicinal chemists, but their synthesis is often problematic. This paper describes a new synthetic pathway toward valuable 3,3-difluoropiperidines starting fr
Electrophile-induced bromocyclization of γ,δ-unsaturated ketimines to intermediate 1-pyrrolinium salts and their selective conversion into novel 5-alkoxymethyl-2-aryl-3-chloropyrroles and 2-aroylpyrroles
D'Hooghe, Matthias,Buyck, Christophe,Contreras, Jan,De Kimpe, Norbert
scheme or table, p. 3667 - 3669 (2009/02/05)
N-(1-Aryl-2,2-dichloropent-4-enylidene)amines were efficiently transformed into 5-bromomethyl-1-pyrrolinium bromides via electrophile-induced bromocyclization. The latter pyrrolinium salts were converted into novel 5-alkoxymethyl-2-aryl-3-chloropyrroles b
Direct electrophilic α-fluorination of imines: Efficient synthesis of mono-and difluoroimines
Verniest, Guido,Van Hende, Eva,Surmont, Riccardo,De Kimpe, Norbert
, p. 4767 - 4770 (2007/10/03)
(Chemical Equation Presented) A mild and efficient procedure to synthesize α-fluoro- and α,α-difluoroimines was developed. Various N-alkylimines derived from acetophenones were successfully monofluorinated using NFSI (N-fluorobenzenesulfonimide) in a mixture of CH3CN and DMF at 0°C. Alternatively, the same procedure without DMF gave rise to difluorinated imines when performed at room temperature. The obtained α- and α,α-difluorinated imines were subsequently reduced to give the corresponding β-fluoro- and β,β-difluoroamines in good yield.
A simple and inexpensive method for the preparation of imines and azadienes
Saoudi,Benguedach,Benhaoua
, p. 2349 - 2354 (2007/10/02)
A number of imines and azadienes were prepared in high yield and good purity by using the condensation reactions of various aldehydes and ketones with amines over natural Algerian bentonite.
Synthesis of 3-Phenylisoquinolones by Reaction of Simple Pyrroline-2,3-diones with Benzyne. New Mechanistic Considerations
Cobas, Agustin,Guitian, Enrique,Castedo, Luis
, p. 3113 - 3117 (2007/10/02)
3-Phenylisoquinolones were obtained by cycloaddition of benzyne to 5-phenylpyrroline-2,3-diones.New mechanistic hypotheses for these transformations are discussed.
