19302-16-0

Basic information

• Product Name: (R)-N-(1-phenylethyl)propan-2-amine
• Synonyms: (R)-N-(1-phenylethyl)propan-2-amine;N-(1-phenylethyl)propan-2-amine;(R,S)-N-(1-Phenylethyl)propan-2-amine;alpha-(Isopropylamino)ethylbenzene;alpha-Methyl-N-(1-methylethyl)benzenemethanamine;N-Isopropyl-1-phenylethylamine
• CAS NO: 19302-16-0
• Molecular Formula: C₁₁H₁₇N
• Molecular Weight: 163.25938
• Mol File: 19302-16-0.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 215℃
• Flash Point: 77℃
• Appearance: /
• Density: 0.898
• PKA: 9.77±0.29(Predicted)
• CAS DataBase Reference: (R)-N-(1-phenylethyl)propan-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(1-phenylethyl)propan-2-amine(19302-16-0)
• EPA Substance Registry System: (R)-N-(1-phenylethyl)propan-2-amine(19302-16-0)

Safety Data

• Hazardous Substances Data: 19302-16-0(Hazardous Substances Data)

Usage

General Description

(R)-N-(1-phenylethyl)propan-2-amine is a chemical compound also known as amphetamine. It is a central nervous system stimulant and a prescription medication used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Amphetamine works by increasing the levels of certain neurotransmitters in the brain, such as dopamine and norepinephrine, which can improve attention and focus. It also has the potential for abuse and dependence, and is classified as a Schedule II controlled substance in the United States. Common side effects of amphetamine include increased blood pressure, heart rate, and alertness, as well as decreased appetite and insomnia. It is important to use this medication only as prescribed by a healthcare professional and to be aware of its potential for misuse and addiction.

Upstream product

• 67-63-0 isopropyl alcohol 
• 618-36-0 rac-methylbenzylamine 
• 108-18-9 diisopropylamine 
• 2627-86-3 (-)-α-methylbenzylamine 
• 75-26-3 isopropyl bromide 
• 67-64-1 acetone 
• 87861-38-9 (R)-N-isopropyl-α-methylbenzylamine 
• 56424-40-9 Isopropylidene-((R)-1-phenyl-ethyl)-amine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 98-86-2 acetophenone 
• 6907-73-9 N-(α-methylbenzylidene)isopropylamine 
• 947503-92-6 N-(1-phenylethylidene)-2-propanamine 
• 613-91-2 acetophenone oxime 
• 98-85-1 1-Phenylethanol 

Downstream Products

• 10403-64-2 N-Isopropyl-N-(1-phenyl-ethyl)-acetamide 
• 118450-87-6 1-isopropyl-2-methyl-2-phenyl-1H-pyrrol-3(2H)-one 
• 569339-08-8 N-isopropyl-4-methoxy-N-(1-phenyl-ethyl)-benzamide 
• 89218-01-9 [(E)-2-(Diphenyl-phosphinoyl)-vinyl]-isopropyl-(1-phenyl-ethyl)-amine 
• 118759-99-2 5-aminomethylene-2,2-dimethyl-1,3-dioxane-4,6-dione 

Relevant articles and documents

Continuous Flow Chiral Amine Racemization Applied to Continuously Recirculating Dynamic Diastereomeric Crystallizations

A new, dynamic diastereomeric crystallization method has been developed, in which the mother liquors are continuously separated, racemized over a fixed-bed catalyst, and recirculated to the crystallizer in a resolution-racemization-recycle (R3) process. S

Imine reduction with me2s-bh3

Although there exists a variety of different catalysts for hydroboration of organic substrates such as aldehydes, ketones, imines, nitriles etc., recent evidence suggests that tetra-coordinate borohydride species, formed by activation, redistribution, or decomposition of boron reagents, are the true hydride donors. We then proposed that Me2S-BH3 could also act as a hydride donor for the reduction of various imines, as similar compounds have been observed to reduce carbonyl substrates. This boron reagent was shown to be an effective and chemoselective hydroboration reagent for a wide variety of imines.

Transformation of N,N-diisopropylarylmethylamines into N-isopropylarylmethylamines with molecular iodine

N,N-Diisopropylarylmethylamines were smoothly converted into the corresponding N-isopropylarylmethylamines by the reaction with molecular iodine in the presence of Na2CO3 in chloroform at 60 °C. Other related tertiary amines were also transformed into the corresponding secondary amines by the reaction with molecular iodine under the same reaction conditions.