69148-92-1

Usage

Uses

Used in Pharmaceutical Industry:
(2,2-DIETHOXY-ETHYL)-ETHYL-AMINE is used as a synthetic intermediate for the preparation of 1-substituted-2-mercaptoimidazoles, which possess antithyroid activity. These compounds are of significant interest due to their potential therapeutic applications in treating thyroid disorders, such as hyperthyroidism and Graves' disease.

InChI:InChI=1/C8H19NO2/c1-4-9-7-8(10-5-2)11-6-3/h8-9H,4-7H2,1-3H3

Upstream product

• 75-04-7 ethylamine 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 621-62-5 chloroacetaldehyde diethyl acetal 
• 64-17-5 ethanol 
• 109-89-7 diethylamine 

Downstream Products

• 10583-83-2 2-mercapto-1-ethylimidazole 
• 1103261-89-7 C₁₇H₂₈N₄O₆ 
• 22944-65-6 2-amino-1-ethylimidazole 

Relevant academic research and scientific papers

New Chiral Auxiliaries and New Optically Pure Ketene Equivalents Derived from Tartaric Acids. Improved Synthesis of (-)-7-Oxabicyclohept-5-en-2-one

Condensation of di-O-acetyl (R,R)- and (S,S)-tartaric anhydride with acetals of N-alkylaminoacetaldehyde gave new chiral auxiliaries (1R,5S,7R)- and (1S,5R,7S)-3-alkyl-2-oxo-3-aza-6,8-dioxabicyclooctane-7-carboxylic (RADO(alkyl)-X and SADO(alkyl)-X) derivatives, respectively.The latter could be used to generate the corresponding 1-cyanovinyl esters that add to furan to give readily crystallizable, optically pure Diels-Alder adducts.The method was illustrated by application to the synthesis of (-)-(1S,4S)-7-oxabicyclohept-5-en-2-one.

Iodine-catalyzed oxidative rearrangement of amines to a-amino acetals and a-amino aldehydes

A protocol for iodine-catalyzed oxidative rearrangement of tertiary and secondary amines has been developed. This metal-free protocol provides an atom-economical, efficient access to synthetically useful a-amino acid derivatives from readily available acyclic and cyclic tertiary or secondary amines.

Iodine-Catalyzed Oxidative Rearrangement of Amines to α-Amino Acetals and α-Amino Aldehydes

A protocol for iodine-catalyzed oxidative rearrangement of tertiary and secondary amines has been developed. This metal-free protocol provides an atom-economical, efficient access to synthetically useful α-amino acid derivatives from readily available acyclic and cyclic tertiary or secondary amines. (Figure presented.).

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antihypertensives and platelet aggregation inhibitors

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles having the general formula: STR1 wherein R1, and R2 and R3 are independently selected from the group consisting of hydrogen, and alkyl (1-6C), and wherein n is an integer equal to 0, 1 or 2, and the pharmaceutically acceptable acid addition salts thereof, are α2 blockers and thus are useful as affectors of the CNS, specifically as platelet aggregation inhibitors and as antihypertensives.

Dioxolane substituted 2,6-dinitroanilines

This invention discloses new chemical compounds of the formula STR1 wherein R1 is alkyl; R2 and R3 are hydrogen or alkyl; and X is selected from the group consisting of alkyl and haloalkyl, and their utility as herbicides.