69148-92-1

Basic information

• Product Name: (2,2-DIETHOXY-ETHYL)-ETHYL-AMINE
• Synonyms: 2,2-DIETHOXY-N-ETHYL-ETHANAMINE;(2,2-DIETHOXY-ETHYL)-ETHYL-AMINE;2,2-DIETHOXY-N-ETHYL-1-ETHANAMINE
• CAS NO: 69148-92-1
• Molecular Formula: C₈H₁₉NO₂
• Molecular Weight: 161.24
• Mol File: 69148-92-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 185.4°C at 760 mmHg
• Flash Point: 73.7°C
• Appearance: /
• Density: 0.883g/cm³
• Vapor Pressure: 0.698mmHg at 25°C
• Refractive Index: 1.419
• PKA: 8.52±0.28(Predicted)
• CAS DataBase Reference: (2,2-DIETHOXY-ETHYL)-ETHYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (2,2-DIETHOXY-ETHYL)-ETHYL-AMINE(69148-92-1)
• EPA Substance Registry System: (2,2-DIETHOXY-ETHYL)-ETHYL-AMINE(69148-92-1)

Safety Data

• Hazardous Substances Data: 69148-92-1(Hazardous Substances Data)

Usage

Uses

2,2-Diethoxy-N-ethylethanamine is used in the preparation of 1-substituted-2-mercaptoimidazoles with antithyroid activity.

InChI:InChI=1/C8H19NO2/c1-4-9-7-8(10-5-2)11-6-3/h8-9H,4-7H2,1-3H3

Upstream product

• 64-17-5 ethanol 
• 109-89-7 diethylamine 
• 75-04-7 ethylamine 
• 621-62-5 chloroacetaldehyde diethyl acetal 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 

Downstream Products

• 1103261-89-7 C₁₇H₂₈N₄O₆ 
• 22944-65-6 2-amino-1-ethylimidazole 
• 10583-83-2 2-mercapto-1-ethylimidazole 

Relevant articles and documents

New Chiral Auxiliaries and New Optically Pure Ketene Equivalents Derived from Tartaric Acids. Improved Synthesis of (-)-7-Oxabicyclohept-5-en-2-one

Condensation of di-O-acetyl (R,R)- and (S,S)-tartaric anhydride with acetals of N-alkylaminoacetaldehyde gave new chiral auxiliaries (1R,5S,7R)- and (1S,5R,7S)-3-alkyl-2-oxo-3-aza-6,8-dioxabicyclooctane-7-carboxylic (RADO(alkyl)-X and SADO(alkyl)-X) derivatives, respectively.The latter could be used to generate the corresponding 1-cyanovinyl esters that add to furan to give readily crystallizable, optically pure Diels-Alder adducts.The method was illustrated by application to the synthesis of (-)-(1S,4S)-7-oxabicyclohept-5-en-2-one.

Iodine-Catalyzed Oxidative Rearrangement of Amines to α-Amino Acetals and α-Amino Aldehydes

A protocol for iodine-catalyzed oxidative rearrangement of tertiary and secondary amines has been developed. This metal-free protocol provides an atom-economical, efficient access to synthetically useful α-amino acid derivatives from readily available acyclic and cyclic tertiary or secondary amines. (Figure presented.).

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antihypertensives and platelet aggregation inhibitors

2-(1,4-Benzodioxan-2-ylalkyl)imidazoles having the general formula: STR1 wherein R1, and R2 and R3 are independently selected from the group consisting of hydrogen, and alkyl (1-6C), and wherein n is an integer equal to 0, 1 or 2, and the pharmaceutically acceptable acid addition salts thereof, are α2 blockers and thus are useful as affectors of the CNS, specifically as platelet aggregation inhibitors and as antihypertensives.