69155-76-6

Basic information

• Product Name: 6-FLUORO-3-FORMYLCHROMONE
• Synonyms: TIMTEC-BB SBB005562;AKOS BBS-00001397;6-FLUORO-4-OXO-4H-CHROMENE-3-CARBALDEHYDE;6-FLUOROCHROMONE-3-CARBOXALDEHYDE;6-FLUORO-3-FORMYLCHROMONE;6-FLUOROCHROMONE-3-CARBOXALDEHYDE 97%;6-fluoro-2-oxo-chromene-3-carbaldehyde
• CAS NO: 69155-76-6
• Molecular Formula: C₁₀H₅FO₃
• Molecular Weight: 192.14
• Product Categories: Heterocyclic Compounds
• Mol File: 69155-76-6.mol
• Article Data: 26

Chemical Properties

• Melting Point: 155-160 °C(lit.)
• Boiling Point: 313.7 °C at 760 mmHg
• Flash Point: 138.9 °C
• Appearance: /
• Density: 1.526 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.658
• Sensitive: Air Sensitive
• CAS DataBase Reference: 6-FLUORO-3-FORMYLCHROMONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-3-FORMYLCHROMONE(69155-76-6)
• EPA Substance Registry System: 6-FLUORO-3-FORMYLCHROMONE(69155-76-6)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 69155-76-6(Hazardous Substances Data)

Usage

Uses

6-Fluorochromone-3-carboxaldehyde may be used in the synthesis of the following fluorine-containing chromone-tetrazoles:3-((1-cyclohexyl-1H-tetrazol-5-yl)(phenylamino)methyl)-6-fluoro-4H-chromen-4-one3-((1-cyclohexyl-1H-tetrazol-5-yl)((3,4,5-trimethoxyphenyl)amino)methyl)-6-fluoro-4H-chrome-4-one3-((1-(tert-butyl)-1H-tetrazol-5-yl)(phenylamino)methyl)-6-fluoro-4H-chromen-4-one3-((1-(tert-butyl)-1H-tetrazol-5-yl)((4-chlorophenyl)amino)methyl)-6-fluoro-4H-chromen-4-one

InChI:InChI=1/C10H5FO3/c11-8-1-2-9-6(4-8)3-7(5-12)10(13)14-9/h1-5H

Upstream product

• 347-54-6 5-fluoro-2-hydroxybenzaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 405-51-6 4-fluorophenyl acetate 
• 371-41-5 4-Fluorophenol 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 1411983-47-5 3-bromo-N′-((6-fluoro-4-oxo-4H-chromen-3-yl)methylene)benzohydrazide 
• 64481-25-0 C₁₂H₇FO₄ 
• 1203451-86-8 ethyl 3-chloro-5-(5-fluoro-2-hydroxybenzoyl)-2-hydroxybenzoate 
• 1162661-58-6 ethyl 3-(5-(5-fluoro-2-hydroxybenzoyl)-2-hydroxyphenyl)-3-oxopropanoate 
• 1162661-48-4 ethyl 3-acetyl-5-(5-fluoro-2-hydroxybenzoyl)-2-hydroxybenzoate 
• 1063738-07-7 6-fluoro-3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl)vinyl)-4H-chromen-4-one 
• 924213-28-5 (5-fluoro-2-hydroxyphenyl)[2-(3-hydroxypropyl)[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methanone 

Relevant articles and documents

Identification of potent α-amylase inhibitors via dynamic combinatorial chemistry

In this study, we report for the first time the discovery of potent α-amylase inhibitors using principle of dynamic combinatorial chemistry. The best compound identified exhibited not only high inhibitory efficiency but also low cytotoxicity. The binding mode and possible mechanism are determined in the subsequent kinetic and molecular docking studies.

Polysubstituted heterocyclic derivative, preparation method thereof and application of polysubstituted heterocyclic derivative in medicine

The invention provides a polysubstituted heterocyclic derivative, a preparation method thereof and application of the polysubstituted heterocyclic derivative in medicine, and belongs to the technical field of medicinal chemistry. The polysubstituted heterocyclic derivative is a compound shown in a general formula I or II, a pharmaceutically acceptable salt or a solvate of the compound, and the compound can inhibit mRNA demethylase on the protease level and is used for treating diseases related to mRNA demethylase functions.

Discovery of Novel Chromone Derivatives Containing a Sulfonamide Moiety as Anti-ToCV Agents through the Tomato Chlorosis Virus Coat Protein-Oriented Screening Method

A number of novel chromone derivatives containing sulfonamide moieties were designed and synthesized, and the activity of compounds against tomato chlorosis virus (ToCV) was assessed using the ToCVCP-oriented screening method. Comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) models were established based on the dissociation constant (Kd) values of the target compounds, and compound 35 was designed and synthesized with the aid of CoMFA and CoMSIA models. The study of affinity interaction indicated that compound 35 exhibited excellent affinity with ToCVCP with a Kd value of 0.11 μM, which was better than that of the positive control agents xiangcaoliusuobingmi (0.44 μM) and ningnanmycin (0.79 μM). In addition, the in vivo inhibitory effect of compound 35 on the ToCVCP gene was evaluated by the quantitative real-time polymerase chain reaction. ToCVCP gene expression levels of the compound 35 treatment group were reduced by 67.2%, which was better than that of the positive control agent ningnanmycin (59.5%). Therefore, compound 35 can be used as a potential anti-ToCV drug in the future.