1333340-14-9Relevant academic research and scientific papers
Conversion of a Benzofuran Ester to an Amide through an Enamine Lactone Pathway: Synthesis of HCV Polymerase Inhibitor GSK852A
Bowman, Roy K.,Bullock, Kae M.,Copley, Royston C. B.,Deschamps, Nicole M.,McClure, Michael S.,Powers, Jeremiah D.,Wolters, Andy M.,Wu, Lianming,Xie, Shiping
, p. 9610 - 9619 (2015/10/12)
HCV NS5B polymerase inhibitor GSK852A (1) was synthesized in only five steps from ethyl 4-fluorobenzoylacetate (3) in 46% overall yield. Key to the efficient route was the synthesis of the highly functionalized benzofuran core 15 from the β-keto ester in
Facile functionalization at the C2 position of a highly substituted benzofuran
He, Shuwen,Li, Peng,Dai, Xing,McComas, Casey C.,Du, Chunyan,Wang, Ping,Lai, Zhong,Liu, Hong,Yin, Jingjun,Bulger, Paul G.,Dang, Qun,Xiao, Dong,Zorn, Nicolas,Peng, Xuanjia,Nargund, Ravi P.,Palani, Anandan
supporting information, p. 2212 - 2216 (2014/04/17)
To expedite an SAR study of the C2 position of a highly substituted benzofuran ring system, we developed a method for the preparation of a key precursor, iodide 10. From iodide 10, a diverse set of compounds with different substituents at the C2 position were prepared efficiently.
TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
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Paragraph 0784, (2014/08/07)
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
