1307255-36-2

Upstream product

• 75-16-1 methylmagnesium bromide 
• 54881-49-1 2-chloro-3-methoxy benzaldehyde 

Downstream Products

• 1307255-38-4 tert-butyl (3-endo)-3-(3-acetyl-2-chlorophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1307255-37-3 1-(2-chloro-3-methoxyphenyl)ethanone 
• 69240-96-6 1-(2-chloro-3-hydroxyphenyl)ethanone 

Relevant academic research and scientific papers

SMYD INHIBITORS

The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE

Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof (In the formula, A represents a group that is represented by formula (A-1); R1a and R1b may be the same or different and each independently represents a C1-6 alkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; X1 represents a hydroxyl group or an aminocarbonyl group; Z1 represents a single bond or the like; and R2 represents an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group or the like.)