69248-34-6Relevant articles and documents
Direct Stereoselective Installation of Alkyl Fragments at the β-Carbon of Enals via Excited Iminium Ion Catalysis
Verrier, Charlie,Alandini, Nurtalya,Pezzetta, Cristofer,Moliterno, Mauro,Buzzetti, Luca,Hepburn, Hamish B.,Vega-Pe?aloza, Alberto,Silvi, Mattia,Melchiorre, Paolo
, p. 1062 - 1066 (2018)
The direct introduction of sp3 carbon fragments at the β position of α,β-unsaturated aldehydes is greatly complicated by competing 1,2-addition manifolds. Previous catalytic enantioselective conjugate addition methods, based on the use of organometallic reagents or ground-state iminium ion activation, could not provide general and efficient solutions. We report herein that, by turning them into strong oxidants, visible light excitation of chiral iminium ions triggers a stereocontrolled radical pathway that exclusively affords highly enantioenriched β-substituted aldehydes bearing a variety of alkyl fragments.
Virtually complete blocking of α,β-unsaturated aldehyde carbonyls by complexation with aluminum tris(2,6-diphenylphenoxide)
Maruoka, Keiji,Imoto, Hiroshi,Saito, Susumu,Yamamoto, Hisashi
, p. 4131 - 4132 (2007/10/02)
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