6927-73-7

Basic information

• Product Name: P-BUTYLOXYANILINE HYDROCHLORIDE
• Synonyms: P-BUTYLOXYANILINE HYDROCHLORIDE
• CAS NO: 6927-73-7
• Molecular Formula: C₁₀H₁₅NO*ClH
• Molecular Weight: 0
• Mol File: 6927-73-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 312.8°C at 760 mmHg
• Flash Point: 143°C
• Appearance: /
• Vapor Pressure: 0.000382mmHg at 25°C
• CAS DataBase Reference: P-BUTYLOXYANILINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: P-BUTYLOXYANILINE HYDROCHLORIDE(6927-73-7)
• EPA Substance Registry System: P-BUTYLOXYANILINE HYDROCHLORIDE(6927-73-7)

Safety Data

• Hazardous Substances Data: 6927-73-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H15NO.ClH/c1-2-3-8-12-10-6-4-9(11)5-7-10;/h4-7H,2-3,8,11H2,1H3;1H

Upstream product

• 103-90-2 4-acetaminophenol 
• 23563-26-0 4-n-butoxyacetanilide 

Downstream Products

• 371112-57-1 CH₃(CH₂)8OC₆H₄COCHCHNHC₆H₄O(CH₂)3CH₃ 
• 72238-89-2 1-(4-Butoxy-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diamine; hydrochloride 

Relevant articles and documents

Comparative Structure-Activity Relationships of Antifolate Triazines Inhibiting Murine Tumor Cells Sensitive and Resistant to Methotrexate

The inhibitory effect of 108 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines on murine L5178Y tumor cells, resistant and sensitive to methotrexate (MTX), has been studied.From the pI50 values, quantitative structure-activity relationships have been formulated which show that the lipophilic triazines are much more inhibitory against resistant cells than methotrexate or hydrophilic triazines.The results are compared with the behavior of other antifolate drugs that have been used in chemotherapy, as well as with eight antitumor drugs that are notantifolates.The acquired resistance of these cells toward hydrophilic antifolates may be attributed to the combined effect of an impaired active-transport system, a change in the conformation of dihydrofolate reductase in the resistant cells, and an amplified production of dihydrofolate reductase in the resistant cells.