72238-89-2

Basic information

• Product Name: 1-(4-butoxyphenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride (1:1)
• Synonyms: 1-(4-Butoxyphenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride (1:1); 1,3,5-triazine-2,4-diamine, 1-(4-butoxyphenyl)-1,6-dihydro-6,6-dimethyl-, hydrochloride (1:1); TCMDC-124279
• CAS NO: 72238-89-2
• Molecular Formula: C₁₅H₂₄ClN₅O
• Molecular Weight: 325.837
• Mol File: 72238-89-2.mol

Chemical Properties

• Boiling Point: 445.3°C at 760 mmHg
• Flash Point: 223.1°C
• Vapor Pressure: 4E-08mmHg at 25°C
• CAS DataBase Reference: 1-(4-butoxyphenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-butoxyphenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride (1:1)(72238-89-2)
• EPA Substance Registry System: 1-(4-butoxyphenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride (1:1)(72238-89-2)

Safety Data

• Hazardous Substances Data: 72238-89-2(Hazardous Substances Data)

Upstream product

• 23563-26-0 4-n-butoxyacetanilide 
• 103-90-2 4-acetaminophenol 
• 127099-85-8 dicyandiamide 
• 6927-73-7 4-butyloxyphenylamine hydrochloride 
• 67-64-1 acetone 

Relevant articles and documents

Comparative Structure-Activity Relationships of Antifolate Triazines Inhibiting Murine Tumor Cells Sensitive and Resistant to Methotrexate

The inhibitory effect of 108 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines on murine L5178Y tumor cells, resistant and sensitive to methotrexate (MTX), has been studied.From the pI50 values, quantitative structure-activity relationships have been formulated which show that the lipophilic triazines are much more inhibitory against resistant cells than methotrexate or hydrophilic triazines.The results are compared with the behavior of other antifolate drugs that have been used in chemotherapy, as well as with eight antitumor drugs that are notantifolates.The acquired resistance of these cells toward hydrophilic antifolates may be attributed to the combined effect of an impaired active-transport system, a change in the conformation of dihydrofolate reductase in the resistant cells, and an amplified production of dihydrofolate reductase in the resistant cells.