6928-51-4

Usage

Also known as

3,4-dihydro-2-phenyl-2H-benzo[e][1,2]thiopyran-4-ol
Heterocyclic organic compound containing oxygen and sulfur in its molecular structure
Used as a building block in the synthesis of pharmaceuticals and agrochemicals
Valuable intermediate in the production of biologically active compounds
Potential applications in research and development in medicine and agriculture

Upstream product

• 784-62-3 1-thioflavone 
• 491-39-4 thiochromen-4-one 
• 551-93-9 2-aminoacetophenone 
• 300657-41-4 (E)-1-(2-bromophenyl)-3-phenylprop-2-en-1-one 
• 107921-63-1 (E)-1-(2-iodophenyl)-3-phenylprop-2-en-1-one 
• 5962-00-5 2-phenyl-thiochroman-4-one 

Relevant academic research and scientific papers

Conjugate addition of grignard reagents to thiochromones catalyzed by copper salts: A unified approach to both 2-alkylthiochroman-4-one and thioflavanone

Grignard reagents undergo conjugate addition to thiochromones catalyzed by copper salts to afford 2-substituted-thiochroman-4-ones, both 2-alkylthiochroman-4-ones and thioflavanones (2-arylthiochroman-4-ones), in good yields with trimethylsilyl chloride (TMSCl) as an additive. The best yields of 1,4-adducts can be attained with CuCN-2LiCl as the copper source. Excellent yields of 2-alkyl-substituted thiochroman-4-ones and thioflavanones (2-aryl substituted) are attained with a broad range of Grignard reagents. This approach works well with both alkyl and aromatic Grignard reagents, thus providing a unified synthetic approach to privileged 2-substituted thiochroman-4-ones and a potential valuable precursor for further synthetic applications towards many pharmaceutically active molecules. The use of commercially available and/or readily prepared Grignard reagents will expedite the synthesis of a large library of both 2-alkyl substituted thiochroman-4-ones and thioflavanones for additional synthetic applications.

Copper-Catalyzed Domino Synthesis of 2-Arylthiochromanones through Concomitant C-S Bond Formations Using Xanthate as Sulfur Source

An efficient domino process for the synthesis of thioflavanones has been described using a copper catalyst without addition of any external ligand. A variety of thioflavanones have been synthesized from easily accessible 2′-iodochalcones or 2′-bromochalco

Synthesis, characterization, and redox property of 3-(2-phenyl-4H- thiochromen-4-ylidene)-3H-chromene-2,4-diones

Two 3-(2-phenyl-4H-thiochromen-4-ylidene)-3H-chromene-2,4-dione derivatives were synthesized and evaluated as reversible redox switches. The prepared purple compound 7 and blue compound 13 instantly changed to colorless when treated with sodium borohydrid