300657-41-4

Basic information

• Product Name: (E)-1-(2-bromophenyl)-3-phenylprop-2-en-1-one
• Synonyms: (E)-1-(2-bromophenyl)-3-phenylprop-2-en-1-one
• CAS NO: 300657-41-4
• Molecular Weight: 287.156
• Mol File: 300657-41-4.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: (E)-1-(2-bromophenyl)-3-phenylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(2-bromophenyl)-3-phenylprop-2-en-1-one(300657-41-4)
• EPA Substance Registry System: (E)-1-(2-bromophenyl)-3-phenylprop-2-en-1-one(300657-41-4)

Safety Data

• Hazardous Substances Data: 300657-41-4(Hazardous Substances Data)

Upstream product

• 2142-69-0 2-bromophenyl methyl ketone 
• 100-52-7 benzaldehyde 
• 134419-85-5 2-bromo-α-(phenylethynyl)-benzenemethanol 
• 98-86-2 acetophenone 
• 6630-33-7 ortho-bromobenzaldehyde 
• 140-10-3 (E)-3-phenylacrylic acid 
• 26767-16-8 2-(2-bromophenyl)-2-oxoacetic acid 

Downstream Products

• 16618-72-7 3-phenyl-1-indanone 
• 634182-03-9 (R)-3-phenyl-2,3-dihydro-1H-inden-1-one 
• 634182-04-0 (S)-3-phenyl-2,3-dihydro-1H-inden-1-one 
• 1422961-05-4 C₂₃H₂₇BO₄ 
• 1422960-89-1 C₂₁H₂₃BO₃ 
• 1422961-04-3 C₁₇H₁₅BrO₂ 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 120642-65-1 3-(5-phenyl-1,2,3-triazole-4-yl)-<2,1>-benzisoxazole 
• 1206545-03-0 1-(2-bromophenyl)-3-phenyl-1-propanone 
• 1370701-00-0 (E)-1-(2-bromophenyl)-3-phenylprop-2-en-1-ol 
• 337921-66-1 C₂₀H₁₄O₂ 
• 5961-99-9 3,4-Dihydro-2-phenyl-2H-1-benzothiopyran 

Relevant articles and documents

Borane-Catalyzed, Chemoselective Reduction and Hydrofunctionalization of Enones Enabled by B-O Transborylation

The use of stoichiometric organoborane reductants in organic synthesis is well established. Here these reagents have been rendered catalytic through an isodesmic B-O/B-H transborylation applied in the borane-catalyzed, chemoselective alkene reduction and formal hydrofunctionalization of enones. The reaction was found to proceed by a 1,4-hydroboration of the enone and B-O/B-H transborylation with HBpin, enabling catalyst turnover. Single-turnover and isotopic labeling experiments supported the proposed mechanism of catalysis with 1,4-hydroboration and B-O/B-H transborylation as key steps.

Green method for high-selectivity synthesis of chalcone compounds

Under the condition of air, the water-soluble inorganic weak base is used as a catalyst to catalyze the hydrogen transfer reaction of the propargyl alcohol compound, so that the green synthesis of the high-trans selective chalcone compound is realized. Reaction temperature: 80 - 120 °C and reaction time 12 - 48 hours. To the technical scheme, any transition metal catalyst and ligand do not need to be used, inert gas protection is not needed, no other byproducts are generated, the atom economy 100%, green and environment friendliness are avoided, and the product is a high-selectivity (E)-type product. The reaction conditions are relatively low in requirement. Compared with the prior art, the alkali catalyst is obvious in advantages, and has a certain application prospect in the fields of organic synthesis, biochemistry, medicine and the like.

Beyond the Corey–Chaykovsky Reaction: Synthesis of Unusual Cyclopropanoids via Desymmetrization and Thereof

Desymmetrization-based protocols for the synthesis of highly functionalized indeno-spirocyclopropanes and cyclopropa-fused indanes have been established through unexpected reactions triggered by the Corey–Chaykovsky reagent. These structures were further elaborated in one step to privileged scaffolds such as fluorenones, indenones, and naphthaphenones. For instance, an acid-catalyzed transformation of indeno-spirocyclopropanes provided fluorenones via a homo-Nazarov-type cyclization, and naphthaphenones were obtained via an acid-catalyzed cyclopropane ring-opening/retro-Michael sequence.