6928-56-9

Basic information

• Product Name: 3-amino-2-phenyl-4H-chromen-4-one
• Synonyms: 3-aminoflavone
• CAS NO: 6928-56-9
• Molecular Formula: C₁₅H₁₁NO₂
• Molecular Weight: 237.2533
• Mol File: 6928-56-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 386.9°C at 760 mmHg
• Flash Point: 185.5°C
• Density: 1.283g/cm³
• Vapor Pressure: 3.42E-06mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: 3-amino-2-phenyl-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-2-phenyl-4H-chromen-4-one(6928-56-9)
• EPA Substance Registry System: 3-amino-2-phenyl-4H-chromen-4-one(6928-56-9)

Safety Data

• Hazardous Substances Data: 6928-56-9(Hazardous Substances Data)

Usage

General Description

3-Amino-2-phenyl-4H-chromen-4-one, also known as 4H-3-Amino-2-phenyl coumarin, is a chemical compound with a 4H-chromen-4-one core structure and an amino group attached at the 3-position and a phenyl group at the 2-position. It is commonly used in pharmaceutical and medicinal chemistry due to its potential therapeutic properties, such as anti-inflammatory, antioxidant, and anti-cancer activities. 3-Amino-2-phenyl-4H-chromen-4-one has been studied for its potential in the treatment of various diseases, including cancer, diabetes, and cardiovascular diseases. Its unique structure and biological activities make it a valuable target for drug discovery and development. Additionally, it can also serve as a valuable chemical intermediate in organic synthesis for the construction of diverse bioactive molecules.

Upstream product

• 10524-88-6 3-Nitro-2-phenyl-4H-benzopyran-4-one 
• 59507-94-7 3-amino-4H-chromen-4-one 
• 100-63-0 phenylhydrazine 
• 141334-33-0 Phenyl-2 oximino-3 chromanone-4 
• 67139-31-5 trans-3-mesyloxyflavanone 
• 70188-30-6 3-mesyloxyflavone 
• 13800-28-7 3-tosyloxyflavone 
• 94953-78-3 (2R,3R)-2-Phenyl-3-thiocyanato-chroman-4-one 
• 141334-34-1 N-diphenylphosphinyl-3-aminoflavone 
• 141334-35-2 N-(O,O-diethyphosphoro)-3-aminoflavone 
• 70188-21-5 (Z)-α-azido-2'-hydroxychalcone 

Downstream Products

• 70460-60-5 2-phenyl-chroman-3,4-dione 
• 127897-19-2 3-(1-tetrazolyl)flavone 
• 1138343-33-5 Cu(3-aminoflavone)2(NO₃)2 
• 65-85-0 benzoic acid 
• 6965-55-5 3-N-acetylaminoflavone 

Relevant articles and documents

CONTRIBUTION OF THE PYRYLIUM STRUCTURE TO THE ELECTROCHEMICAL PROPERTIES OF NITROFLAVONES

The polarographic behavior of 3- and 4'-nitroflavones on a dropping mercury electrode in Britton-Robinson buffer solutions was investigated.It is shown that, depending on its position, the nitro group displays properties that are typical only for aromatic

The base-induced regioselective radical arylation of 3-aminochromone with aryl hydrazine

A simple and efficient direct radical C-2 arylation of 3-aminochromone derivatives with aryl hydrazine is described. The aryl hydrazine acts as an initiator and source for the aryl radical via the cleavage of the C-N bond of aryl hydrazine. The reaction proceeds via a base-promoted single electron transfer (SET) pathway. The aryl radical abstracts a single electron from 3-aminochromone, which generates a C2-radical iminium ion to undergo a cross-coupling reaction with an aryl radical, and this process offers an array of regioselective 2-aryl substituted 3-aminochromones. This journal is

Regioselective 3-nitration of flavones: A new synthesis of 3-nitro- and 3-aminoflavones

A new, general, and regioselective method for the 3-nitration of flavones have been developed. The nitration reaction is solvent dependent, proceeds via a nitro radical pathway, and the corresponding 3-nitroflavones have been obtained in moderate to very