69296-06-6

Basic information

• Product Name: 2-morpholin-4-ylpropan-1-ol
• Synonyms: 2-morpholin-4-ylpropan-1-ol
• CAS NO: 69296-06-6
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.1995
• Mol File: 69296-06-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-morpholin-4-ylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-morpholin-4-ylpropan-1-ol(69296-06-6)
• EPA Substance Registry System: 2-morpholin-4-ylpropan-1-ol(69296-06-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 69296-06-6(Hazardous Substances Data)

Upstream product

• 6168-72-5 2-Amino-1-propanol 
• 111-44-4 3-oxa-1,5-dichloropentane 
• 110-91-8 morpholine 
• 75-56-9 methyloxirane 
• 110073-17-1 2-morpholinopropionic acid methyl ester 

Relevant articles and documents

Tetranuclear Zn complex covalently immobilized on sulfopropylsilylated mesoporous silica: An efficient catalyst for ring opening reaction of epoxide with amine

Tetranuclear Zn complex, [Zn4(L)2(LH)2((CH3)2SO)2]·2CH3OH·(CH3)2SO·H2O (1) [where LH3 = 3-(E)-(2-hydroxyphenylimino)methyl-4-hydroxy-5-hydroxymethylphenyl (LH3)] was prepared and characterized by single-crystal X-ray analysis. Then, it was incorporated to the sulfopropylsilylated MCM-48, MCM-41 and SBA-15 mesoporous silica materials. The prepared materials were thoroughly characterized by XRD, FT-IR, N2 adsorption/desorption analysis, NH3-TPD, TGA, SEM-EDX and ICP-OES measurements. These catalysts were successfully used for the ring opening reaction of propylene oxide with morpholine producing the corresponding β-aminoalcohols. An abrupt increase in catalytic activities was observed after anchoring of the tetranuclear Zn complex onto the inner surface of sulfopropylsilylated mesoporous materials. Among all the catalysts, the tetranuclear Zn complex incorporated MCM-48 was found to be most active in this reaction system and gave maximum 95% conversion. Catalysis by the tetranuclear Zn complex immobilized on MCM-48 was totally heterogeneous and the catalyst was recyclable up to 4 times without leaching.

SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE

The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.

SUBSTITUTED ANTHRANILIC AMIDE DERIVATIVES AND METHODS OF USE

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.