69311-06-4Relevant academic research and scientific papers
Concise synthesis of α-cyano tetrahydroisoquinolines with a quaternary centerviaStrecker reaction
Han, Weiwei,Ji, Yue,Wang, Sichang,Wei, Yitao,Wu, Ya,Xiao, Pei,Yang, Penghui,Zhang, Keliang,Zhang, Xue
, p. 38712 - 38716 (2021/12/21)
A concise synthesis of α-cyano tetrahydroisoquinolines with a quaternary centerviathe Strecker reaction was successfully realized by employing TMSCN as cyano source and KF as fluoride source, furnishing the products with up to 99% yield. An isomerization
Reactions of N-quaternary 1-phenyl-3,4-dihydroisoquinolinium compounds with nucleophiles - Products and their isomerism - Part 1
Moehrle,Breves
, p. 181 - 191 (2007/10/03)
Variously substituted 1-phenyl-3,4-dihydroisoquinolinium compounds were prepared, in order to study their reactions with hydroxide ions concerning ring-chain isomerism of their products. Thereby was observed a dependence on the electrophilic properties of
Studies on cerebral protective agents. IX. Synthesis of novel 1,2,3,4-tetrahydroisoquinolines as N-methyl-D-aspartate antagonists
Ohkubo, Mitsuru,Kuno, Atsushi,Katsuta, Kiyotaka,Ueda, Yoshiko,Shirakawa, Kiyoharu,Nakanishi, Hajime,Nakanishi, Isao,Kinoshita, Takayoshi,Takasugi, Hisashi
, p. 95 - 102 (2007/10/03)
A series of 1,2,3,4-tetrahydroisoquinoline derivatives were synthesized and evaluated for anticonvulsant activity against intracerebro-ventriculas (i.c.v.) N-methyl-D-aspartate (NMDA)-induced seizures in mice. Among these compounds, (+)-1-methyl-1-phenyl-
