693248-12-3

Basic information

• Product Name: 2-tert-butoxy-5-trifluoromethylbenzonitrile
• Synonyms: 2-tert-butoxy-5-trifluoromethylbenzonitrile
• CAS NO: 693248-12-3
• Molecular Weight: 243.229
• Mol File: 693248-12-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-tert-butoxy-5-trifluoromethylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-butoxy-5-trifluoromethylbenzonitrile(693248-12-3)
• EPA Substance Registry System: 2-tert-butoxy-5-trifluoromethylbenzonitrile(693248-12-3)

Safety Data

• Hazardous Substances Data: 693248-12-3(Hazardous Substances Data)

Upstream product

• 4088-84-0 2-fluoro-5-trifluoromethyl-benzonitrile 
• 865-48-5 sodium t-butanolate 
• 865-47-4 potassium tert-butylate 

Downstream Products

• 860797-26-8 C₂₈H₃₃F₃N₂O₅ 
• 860797-25-7 C₂₇H₃₁F₃N₂O₅ 
• 1401995-12-7 8-isopropyl-3-methyl-2-oxo-1-oxa-8-aza-spiro[4.5]dec-3-ene-4-carboxylic acid 2-hydroxy-5-trifluoromethyl-benzylamide 
• 1401995-11-6 8-isopropyl-3-methyl-2-oxo-1-oxa-8-aza-spiro[4.5]dec-3-ene-4-carboxylic acid 2-tert-butoxy-5-trifluoromethyl-benzylamide 
• 693248-13-4 (2-(tert-butoxy)-5-(trifluoromethyl)phenyl)methanamine 
• 782493-18-9 (1S)-N-[2-tert-butoxy-5-(trifluoromethyl)benzyl]-1-isopropyl-3-oxocyclopentanecarboxamide 

Relevant articles and documents

CCR2 MODULATORS

Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I) and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of CCR2 receptors.

SPIROALKENE CARBOXAMIDE DERIVATIVES AND THEIR USE AS CHEMOKINE RECEPTOR MODULATORS

The present invention is directed to compounds of Formula (I) below, which are antagonists to the chemoattractant cytokine receptor 2 (CCR2), and/or 5 (CCR5), pharmaceutical compositions, and methods for use thereof.

BENZOXAZINYL-AMIDOCYCLOPENTYL-HETEROCYCLIC MODULATORS OF CHEMOKINE RECEPTORS

Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula I: which are used to modulate the CCR-2 chemokine receptor to prevent or treat inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions.