693248-13-4

Basic information

• Product Name: (2-tert-butoxy-5-(trifluoromethyl)phenyl)methanamine
• Synonyms: (2-tert-butoxy-5-(trifluoromethyl)phenyl)methanamine
• CAS NO: 693248-13-4
• Molecular Weight: 247.26
• Mol File: 693248-13-4.mol

Chemical Properties

• CAS DataBase Reference: (2-tert-butoxy-5-(trifluoromethyl)phenyl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (2-tert-butoxy-5-(trifluoromethyl)phenyl)methanamine(693248-13-4)
• EPA Substance Registry System: (2-tert-butoxy-5-(trifluoromethyl)phenyl)methanamine(693248-13-4)

Safety Data

• Hazardous Substances Data: 693248-13-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(2-tert-butoxy-5-(trifluoromethyl)phenyl)methanamine is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into various drug molecules, contributing to their overall structure and potential therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical field, (2-tert-butoxy-5-(trifluoromethyl)phenyl)methanamine serves as an intermediate in the production of agrochemicals, playing a role in the development of compounds that can protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
(2-tert-butoxy-5-(trifluoromethyl)phenyl)methanamine is utilized as a building block in organic synthesis, allowing for the creation of a wide range of organic compounds for various applications, including but not limited to, materials science, specialty chemicals, and research reagents.

Upstream product

• 4088-84-0 2-fluoro-5-trifluoromethyl-benzonitrile 
• 693248-12-3 2-tert-butoxy-5-trifluoromethylbenzonitrile 

Downstream Products

• 782493-34-9 N-[2-tert-butoxy-5-(trifluoromethyl)benzyl]-1-(1-hydroxyethyl)-3-oxocyclopentanecarboxamide 
• 782493-18-9 (1S)-N-[2-tert-butoxy-5-(trifluoromethyl)benzyl]-1-isopropyl-3-oxocyclopentanecarboxamide 
• 1401995-11-6 8-isopropyl-3-methyl-2-oxo-1-oxa-8-aza-spiro[4.5]dec-3-ene-4-carboxylic acid 2-tert-butoxy-5-trifluoromethyl-benzylamide 
• 1401995-12-7 8-isopropyl-3-methyl-2-oxo-1-oxa-8-aza-spiro[4.5]dec-3-ene-4-carboxylic acid 2-hydroxy-5-trifluoromethyl-benzylamide 
• 1349197-78-9 C₂₀H₂₄F₃N₃O₃ 

Relevant articles and documents

CCR2 MODULATORS

Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I) and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of CCR2 receptors.

SPIROALKENE CARBOXAMIDE DERIVATIVES AND THEIR USE AS CHEMOKINE RECEPTOR MODULATORS

The present invention is directed to compounds of Formula (I) below, which are antagonists to the chemoattractant cytokine receptor 2 (CCR2), and/or 5 (CCR5), pharmaceutical compositions, and methods for use thereof.

Spiroalkene carboxamide derivatives and their use as chemokine receptor modulators

The present invention is directed to compounds of Formula (I) below, which are antagonists to the chemoattractant cytokine receptor 2 (CCR2), and/or 5 (CCR5), pharmaceutical compositions, and methods for use thereof.

Discovery of a potent and orally bioavailable CCR2 and CCR5 dual antagonist

This report describes the discovery of a potent, orally bioavailable CC chemokine receptor 2 (CCR2) antagonist which, while optimized for CCR2 potency, also had potent CC chemokine receptor 5 (CCR5) activity.

BENZOXAZINYL-AMIDOCYCLOPENTYL-HETEROCYCLIC MODULATORS OF CHEMOKINE RECEPTORS

Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula I: which are used to modulate the CCR-2 chemokine receptor to prevent or treat inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions.

ALKYLAMINO, ARYLAMINO, AND SULFONAMIDO CYCLOPENTYL AMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Compounds of the formula (I) which are modulators of chemokine receptor activity useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis, and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.

BENZOXAZINYL-AMIDOCYCLOPENTYL-HETEROCYCLIC MODULATORS OF CHEMOKINE RECEPTORS

Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula (I): which are used to modulate the CCR-