6933-47-7Relevant academic research and scientific papers
FUSED PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROTIC DISEASES
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Paragraph 0380-0381, (2021/02/25)
The present invention discloses compounds according to Formula I: Wherein A, B, R1, R2, and Cy are as defined herein. The present invention relates to compounds inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, pain, and/or abnormal angiogenesis associated diseases by administering the compounds of the invention.
THIAZOLIDINONE COMPOUNDS AND USE THEREOF
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Paragraph 0175-0176, (2017/09/21)
A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.
PYRAZOLE COMPOUNDS AS CRTH2 ANTAGONISTS
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Page/Page column 44, (2012/02/06)
The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2-activity, wherein W, L1, L2, X, L3, Y, R1 and R2 are as defined in the spe
Insecticidal 4-phenyl-1H-pyrazoles
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Page/Page column 28, (2011/08/08)
The present invention relates to novel 4-phenyl-1H-pyrazoles and their use as insecticides and/or parasiticides and also to processes for their preparation and to compositions comprising such phenylpyrazoles.
PYRAZOLE COMPOUNDS AS CRTH2 ANTAGONISTS
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Page/Page column 76, (2011/08/21)
The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2-activity, wherein W, L1, L2, X, L3, Y, R1 and R2 are as defined in the spe
INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS
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Page/Page column 29, (2009/05/30)
There is provided according to the invention novel compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: (I) useful as PPAR activators.
Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains
Mayasundari, Anand,Ferreira, Antonio M.,He, Liwen,Mahindroo, Neeraj,Bashford, Don,Fujii, Naoaki
, p. 942 - 945 (2008/09/18)
This report describes the first small-molecule antagonists that specifically target the ligand-binding pocket of PDZ domains of NHERF1 multi-functional adaptor protein. Comparison of the peptide sequence homology between the native ligand of NHERF1 PDZ do
Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity
Mahindroo, Neeraj,Punchihewa, Chandanamali,Bail, Allison M.,Fujii, Naoaki
, p. 946 - 949 (2008/09/20)
We designed and synthesized a series of indole-2-amide-based compounds that antagonize interaction between the Dishevelled (Dvl) PDZ domain and a peptide derived from the natural PDZ ligand Frizzled-7 (Fz7). These compounds inhibit Tcf-mediated transcript
BICYCLIC COMPOUNDS USEFUL AS CATHEPSIN S INBHIBITORS
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Page/Page column 46, (2010/11/29)
Compounds of formula (I), wherein R1, R2, R3, Ra and E are are defined within, and pharmaceutically acceptable salts, solvates, hydrates and N-oxides thereof having utility in the treatment of disorders mediated by cathepsin S.
NOVEL ANTITHROMBOTIC SUBSTITUTED PYRROLIDINONES, THE PRODUCTION AND USE THEREOF IN THE FORM OF MEDICAMENTS
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Page/Page column 99, (2008/06/13)
The invention relates to novel substituted pyrrolidines of general formula (I), wherein A, X, B and R1 to R9 are such as defined in the claim 1, and to the tautomers, enantiomers, diastereomers, mixtures and the salts thereof, in par
