69358-86-7

Upstream product

• 591-50-4 iodobenzene 
• 17356-09-1 4-iodocumene 
• 292638-85-8 acrylic acid methyl ester 
• 67-56-1 methanol 
• 3368-21-6 (E)-4-isopropylcinnamic acid 
• 16695-14-0 Malonic acid monomethyl ester 
• 122-03-2 (4-isopropylbenzaldehyde) 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 274907-08-3 (E)-3-(4-isopropylphenyl)-2-propen-1-ol 

Relevant academic research and scientific papers

A kind of carboxylic acid with malonic acid method of esterification reaction of dimethyl ester (by machine translation)

The invention belongs to the field of chemical synthesis and particularly relates to a carboxyl acid compound methyl etherification method. The carboxyl acid compound methyl etherification method comprises the following steps: in a polar solvent, using a carboxyl acid compound and dimethyl malonate as reactants, under the catalysis of a catalyst, and preparing an acid methyl ester compound through the methyl etherification reaction of the carboxyl acid. The method has the advantages of cheap raw materials, easiness in raw material acquisition, low toxicity, high safety, simple neutral salt catalyst and low dosage and is suitable for industrial application.

A practical, chemoselective approach to O-methylation of carboxylic acids with dimethyl malonate

A practical and chemoselective method is described for the O-methylation of carboxylic acids. Dimethyl malonate, a low toxic and commercially available compound was found to be an effective methylating reagent for a variety of carboxylic acids affording methyl ester products in good to high yields and with excellent chemoselectivity, without the use of strong bases as additives. A mechanism involving the utilization of potassium bromide is tentatively proposed.

Synthesis, characterization and antiproliferative activity of β-aryl-ω-iodo-γ-lactones

A convenient pathway for the synthesis of new of β-aryl-ω-iodo- γ-lactones is described. The synthetic route led to both cis and trans isomers which were separated by column chromatography or crystallization. The structures of synthesized compounds were confirmed by spectroscopic methods: IR, NMR and HR-MS. For lactones with naphthyl ring (6e and 7e) the crystal structures were also obtained. The lactones were screened for biological evaluation against cancer line HL-60 (human promyelocytic leukemia). The tests showed that the presence of substituent at the benzene ring does not significantly affect the antiproliferative activity of the compound.

Quantitative structure-activity relationships of pine weevil antifeedants, a multivariate approach

Antifeedant activity of mainly phenylpropanoic, cinnamic, and benzoic acids esters was tested on the pine weevil, Hylobius abietis (L.). Of 105 compounds screened for activity, 9 phenylpropanoates, 3 cinnamates, and 4 benzoates were found to be highly active antifeedants. To understand the structure-activity relationships of these compounds, a multivariate analysis study was performed. A number of molecular and substituent descriptors were calculated and correlated to results from two-choice feeding tests with H. abietis. Three local models were developed that had good internal predictive ability. External test sets showed moderate predictivity. In general, low polarity, small size, and high lipophilicity were characteristics for compounds having good antifeedant activity.

A NOVEL MOLECULAR RECOGNITION IN MONTMORILLONITE IN THE ARYLATION OF ACRYLATES

A novel sequential and preferential substrate selectivity in arylation of acrylates with iodobenzenes by intralamellar montmorilloniteethylsilyldiphenylphosphinepalladium(II) chloride catalyst is reported for the first time.