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693774-26-4

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693774-26-4 Usage

Description

3-Bromophenyl cyclopropyl ketone, with the molecular formula C10H9BrO, is a yellow to brown liquid chemical compound characterized by a distinctive odor. It is a versatile building block in organic synthesis, known for its ability to participate in various chemical reactions, and is primarily utilized in the synthesis of pharmaceuticals and organic compounds.

Uses

Used in Pharmaceutical Synthesis:
3-Bromophenyl cyclopropyl ketone is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to undergo multiple chemical reactions, contributing to the development of new and improved medications.
Used in Organic Compound Synthesis:
In the field of organic chemistry, 3-Bromophenyl cyclopropyl ketone serves as a valuable building block for creating more complex molecules, facilitating the advancement of research and innovation in organic compound development.
Safety Precautions:
It is crucial to handle 3-Bromophenyl cyclopropyl ketone with care, as it is classified as a hazardous chemical. Exposure may result in skin, eye, and respiratory system irritation, necessitating proper safety measures during its use and storage.

Check Digit Verification of cas no

The CAS Registry Mumber 693774-26-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,3,7,7 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 693774-26:
(8*6)+(7*9)+(6*3)+(5*7)+(4*7)+(3*4)+(2*2)+(1*6)=214
214 % 10 = 4
So 693774-26-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H9BrO/c11-9-3-1-2-8(6-9)10(12)7-4-5-7/h1-3,6-7H,4-5H2

693774-26-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (3-bromophenyl)-cyclopropylmethanone

1.2 Other means of identification

Product number -
Other names 3-BROMOPHENYL CYCLOPROPYL KETONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:693774-26-4 SDS

693774-26-4Relevant articles and documents

SMALL MOLECULE MODULATORS OF IL-17

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Page/Page column 83, (2020/09/30)

The present invention relates to a compound according to formula I and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to, to said compounds for use in therapy, to pharmaceutical compositions comprising said

Silylium-Ion-Promoted (5+1) Cycloaddition of Aryl-Substituted Vinylcyclopropanes and Hydrosilanes Involving Aryl Migration

Bonetti, Vittorio,He, Tao,Klare, Hendrik F. T.,Oestreich, Martin,Wang, Guoqiang

supporting information, p. 12186 - 12191 (2020/05/22)

A transition-metal-free (5+1) cycloaddition of aryl-substituted vinylcyclopropanes (VCPs) and hydrosilanes to afford silacyclohexanes is reported. Catalytic amounts of the trityl cation initiate the reaction by hydride abstraction from the hydrosilane, and further progress of the reaction is maintained by self-regeneration of the silylium ions. The new reaction involves a [1,2] migration of an aryl group, eventually furnishing 4- rather than 3-aryl-substituted silacyclohexane derivatives as major products. Various control experiments and quantum-chemical calculations support a mechanistic picture where a silylium ion intramolecularly stabilized by a cyclopropane ring can either undergo a kinetically favored concerted [1,2] aryl migration/ring expansion or engage in a cyclopropane-to-cyclopropane rearrangement.

Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor

Cumming, Jared N.,Smith, Elizabeth M.,Wang, Lingyan,Misiaszek, Jeffrey,Durkin, James,Pan, Jianping,Iserloh, Ulrich,Wu, Yusheng,Zhu, Zhaoning,Strickland, Corey,Voigt, Johannes,Chen, Xia,Kennedy, Matthew E.,Kuvelkar, Reshma,Hyde, Lynn A.,Cox, Kathleen,Favreau, Leonard,Czarniecki, Michael F.,Greenlee, William J.,McKittrick, Brian A.,Parker, Eric M.,Stamford, Andrew W.

scheme or table, p. 2444 - 2449 (2012/05/19)

From an initial lead 1, a structure-based design approach led to identification of a novel, high-affinity iminohydantoin BACE1 inhibitor that lowers CNS-derived Aβ following oral administration to rats. Herein we report SAR development in the S3 and F′ subsites of BACE1 for this series, the synthetic approaches employed in this effort, and in vivo data for the optimized compound.

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