693784-41-7Relevant academic research and scientific papers
Synthesis of the naphthalene-derived inhibitors against Cdc25A dual-specificity protein phosphatase and their biological activity
Shimbashi, Akiko,Tsuchiya, Ayako,Imoto, Masaya,Nishiyama, Shigeru
, p. 61 - 65 (2007/10/03)
The synthesis naphthoquinones exhibited stronger activity than the pyranonaphthoquinone-type compound having moderate inhibitory activity against Cdc25A protein phosphatase. The novel naphthalene-type analogues 14 and 18 and the naphthoquinone-type analog
Synthesis of (±)-pyranonaphthoquinone derivatives, a Cdc25A phosphatase inhibitor
Shimbashi, Akiko,Ishikawa, Yuichi,Nishiyama, Shigeru
, p. 939 - 941 (2007/10/03)
The novel pyranonaphthoquinone 2, carrying Cdc25A phosphatase inhibitory activity, has been successfully synthesized through tricyclic compound 16, which was obtained from 15 by using the intramolecular Michael addition. The precursor 9 was derived from 5
The synthesis and biological activity of pyranonaphthoquione derivatives from Streptomyces sp. and their related substances
Shimbashi, Akiko,Tsuchiya, Ayako,Imoto, Masaya,Nishiyama, Shigeru
, p. 1925 - 1930 (2007/10/03)
The total synthesis of a novel pyranonaphthoquinone (2) having Cdc25A phosphatase inhibitory activity is achieved. The key step in this synthetic pathway is the intramolecular Michael addition for construction of the pyran ring system. The inhibitory acti
