6939-05-5

Usage

Uses

Used in Chemical Research:
2-Chloro-7-nitrofluorene is used as a reference compound for determining solvent dipolarity and polarizability properties. Its distinct molecular structure allows researchers to study and compare the behavior of solvents in various chemical reactions and processes. This application is particularly important in the field of organic chemistry, where understanding solvent effects is crucial for optimizing reaction conditions and predicting outcomes.

InChI:InChI=1/C13H8ClNO2/c14-10-1-3-12-8(6-10)5-9-7-11(15(16)17)2-4-13(9)12/h1-4,6-7H,5H2

Upstream product

• 2523-44-6 2-chloro-9H-fluorene 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 480462-57-5 4-nitro-4'-chloro-[1,1'-biphen-2-yl]methanol 
• 86-73-7 9H-fluorene 
• 6942-36-5 methyl 2-bromo-5-nitrobenzoate 
• 332883-48-4 (2-bromo-5-nitro-phenyl)methanol 
• 607-57-8 2-nitro-9H-fluorene 

Downstream Products

• 6957-60-4 2-chloro-7-nitro-fluoren-9-one 
• 6957-61-5 2-amino-7-chloro-fluoren-9-one 
• 7356-53-8 2-amino-7-chloro-fluoren-9-ol 
• 5096-17-3 N-(7-chloro-fluoren-2-yl)-acetamide 
• 6957-62-6 7-chloro-fluoren-2-ylamine 

Relevant academic research and scientific papers

Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2

Excitatory amino acid transporters (EAATs) play a pivotal role in maintaining glutamate homeostasis in the mammalian central nervous system, with the EAAT-2 subtype thought to be responsible for the bulk of the glutamate uptake in forebrain regions. A complete elucidation of the functional role of EAAT-2 has been hampered by the lack of potent and selective pharmacological tools. In this study, we describe the synthesis and biological activities of novel aryl-ether, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of EAAT-2. Compound (16) represents one of the most potent (IC50 = 85 ± 5 nM) and selective inhibitors of EAAT-2 identified to date.