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6941-17-9

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6941-17-9 Usage

Uses

2-Amino-1-(4-methylphenyl)-1-propanone, also known as Nor-mephedrone is a synthetic cathinone.

Check Digit Verification of cas no

The CAS Registry Mumber 6941-17-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,4 and 1 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6941-17:
(6*6)+(5*9)+(4*4)+(3*1)+(2*1)+(1*7)=109
109 % 10 = 9
So 6941-17-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO/c1-7-3-5-9(6-4-7)10(12)8(2)11/h3-6,8H,11H2,1-2H3

6941-17-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-amino-1-(4-methylphenyl)propan-1-one,hydrochloride

1.2 Other means of identification

Product number -
Other names 4-Aminoacetyl-toluol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6941-17-9 SDS

6941-17-9Synthetic route

C20H29NO5

C20H29NO5

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride
6941-17-9

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether at 20℃; for 16h;92%
(RS)-2-trifluoroacetamido-1-(4-methylphenyl)-1-propanone
742095-35-8

(RS)-2-trifluoroacetamido-1-(4-methylphenyl)-1-propanone

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride
6941-17-9

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In isopropyl alcohol55%
With hydrogenchloride In ethanol Heating;
α-chloro-4-methyl propiophenone
69673-92-3

α-chloro-4-methyl propiophenone

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride
6941-17-9

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 24 h / 20 °C
2: hydrogenchloride / diethyl ether / 16 h / 20 °C
View Scheme
4'-methylpropiophenone
5337-93-9

4'-methylpropiophenone

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride
6941-17-9

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aluminum (III) chloride; bromine / diethyl ether / 0 °C
2: N,N-dimethyl-formamide / 20 °C
3: hydrogenchloride / diethyl ether / 16 h / 20 °C
View Scheme
2-bromo-4'-methylpropiophenone
92821-88-0, 1451-82-7

2-bromo-4'-methylpropiophenone

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride
6941-17-9

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 20 °C
2: hydrogenchloride / diethyl ether / 16 h / 20 °C
View Scheme
toluene
108-88-3

toluene

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride
6941-17-9

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aluminum (III) chloride / dichloromethane / 2 h / 0 °C
2: N,N-dimethyl-formamide / 24 h / 20 °C
3: hydrogenchloride / diethyl ether / 16 h / 20 °C
View Scheme
(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride
6941-17-9

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride

2,5-Dimethyl-3,6-di-p-tolylpyrazine

2,5-Dimethyl-3,6-di-p-tolylpyrazine

Conditions
ConditionsYield
With sodium hydroxide
With ammonia
(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride
6941-17-9

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride

2-amino-1-(4-methylphenyl)-1-propanol
83435-36-3, 87827-97-2, 116865-78-2

2-amino-1-(4-methylphenyl)-1-propanol

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at 25℃; for 48h;
(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride
6941-17-9

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride

2-Ethoxycarbonylamino-4'-methylpropiophenone

2-Ethoxycarbonylamino-4'-methylpropiophenone

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride
6941-17-9

(rac)-2-amino-1-(p-tolyl)propan-1-one hydrochloride

methyl isocyanate
624-83-9

methyl isocyanate

C12H16N2O2

C12H16N2O2

Conditions
ConditionsYield
With triethylamine In acetone at 0℃;

6941-17-9Relevant articles and documents

Phase I metabolites of mephedrone display biological activity as substrates at monoamine transporters

Mayer,Wimmer,Dillon-Carter,Partilla,Burchardt,Mihovilovic,Baumann,Sitte

supporting information, p. 2657 - 2668 (2016/10/19)

Background and Purpose: 4-Methyl-N-methylcathinone (mephedrone) is a synthetic stimulant that acts as a substrate-type releaser at transporters for dopamine (DAT), noradrenaline (NET) and 5-HT (SERT). Upon systemic administration, mephedrone is metabolized to several phase I compounds: the N-demethylated metabolite, 4-methylcathinone (nor-mephedrone); the ring-hydroxylated metabolite, 4-hydroxytolylmephedrone (4-OH-mephedrone); and the reduced keto-metabolite, dihydromephedrone. Experimental Approach: We used in vitro assays to compare the effects of mephedrone and synthetically prepared metabolites on transporter-mediated uptake and release in HEK293 cells expressing human monoamine transporters and in rat brain synaptosomes. In vivo microdialysis was employed to examine the effects of i.v. metabolite injection (1 and 3?mg·kg?1) on extracellular dopamine and 5-HT levels in rat nucleus accumbens. Key Results: In cells expressing transporters, mephedrone and its metabolites inhibited uptake, although dihydromephedrone was weak overall. In cells and synaptosomes, nor-mephedrone and 4-OH-mephedrone served as transportable substrates, inducing release via monoamine transporters. When administered to rats, mephedrone and nor-mephedrone produced elevations in extracellular dopamine and 5-HT, whereas 4-OH-mephedrone did not. Mephedrone and nor-mephedrone, but not 4-OH-mephedrone, induced locomotor activity. Conclusions and Implications: Our results demonstrate that phase I metabolites of mephedrone are transporter substrates (i.e. releasers) at DAT, NET and SERT, but dihydromephedrone is weak in this regard. When administered in vivo, nor-mephedrone increases extracellular dopamine and 5-HT in the brain whereas 4-OH-mephedrone does not, suggesting the latter metabolite does not penetrate the blood–brain barrier. Future studies should examine the pharmacokinetics of nor-mephedrone to determine its possible contribution to the in vivo effects produced by mephedrone.

MAO inhibition by arylisopropylamines: The effect of oxygen substituents at the β-position

Osorio-Olivares, Mauricio,Rezende, Marcos Caroli,Sepulveda-Boza, Silvia,Cassels, Bruce K.,Fierro, Angelica

, p. 4055 - 4066 (2007/10/03)

Twenty-nine arylisopropylamines, substituted at the β-position of their side chain by an oxo, hydroxy, or methoxy group, were evaluated in vitro as MAO-A and MAO-B inhibitors. The oxo derivatives ('cathinones') were in general less active as MAO-A inhibitors than the corresponding arylisopropylamines, but exhibited an interesting MAO-B inhibiting activity, which was absent in the hydroxy, methoxy, and β-unsubstituted analogues. These results suggest that selective affinity for the two MAO isoforms in this family of compounds is modulated not only by the aryl substitution pattern but also by the side-chain substituents on the arylalkylamine scaffold.

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