6942-23-0

Basic information

• Product Name: methyl 6-(diethylamino)-6-oxohexanoate
• CAS NO: 6942-23-0
• Molecular Formula: C₁₁H₂₁NO₃
• Molecular Weight: 215.2893
• Mol File: 6942-23-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 301.2°C at 760 mmHg
• Flash Point: 135.9°C
• Density: 0.987g/cm³
• Vapor Pressure: 0.00107mmHg at 25°C
• Refractive Index: 1.449
• CAS DataBase Reference: methyl 6-(diethylamino)-6-oxohexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 6-(diethylamino)-6-oxohexanoate(6942-23-0)
• EPA Substance Registry System: methyl 6-(diethylamino)-6-oxohexanoate(6942-23-0)

Safety Data

• Hazardous Substances Data: 6942-23-0(Hazardous Substances Data)

Upstream product

• 627-91-8 adipic acid monomethyl ester 
• 35444-44-1 methyl adipoyl chloride 
• 109-89-7 diethylamine 

Relevant articles and documents

A New Route to N-Monosubstituted Thioamides Utilizing Phosphoramidothionates as Reagents for the Thioamidation of Carboxylic Acids

Several N-monosubstituted thioamides have been synthesized from the corresponding carboxylic acid chlorides and primary amines by a new procedure.The procedure utilizes a commercially available and inexpensive organophosphorus reagent (dimethyl chlorothiophosphate) to derivatize the amine, form the carboxamide bond, and accomplish the thionation of the carbonyl by an intramolecular rearrangement.The phosphoryl group is then cleaved from the resulting thiocarbonyl phosphoryl mixed imide by a simple hydrolysis.Thioamides (RCSNHR') containing a variety of functionality(R= simple alkyl, phenyl, bulky alkyl, cycloalkylalkyl, α,β-unsaturated, and alkyl with remote keto, ester, or amide carbonyl groups; R'= methyl, benzyl, allyl) have been prepared by this method in generally high overall yields (50-80 percent).Competing thionation of remote carbonyl groups or epimerization of a chiral center containing a proton α to a ketone group was not observed.