694450-89-0Relevant academic research and scientific papers
Pilot plant preparation of tert-butyl-4-(2-hydroxyethyl)-4-(pyrrolidin-1- yl)-piperidine-1-carboxylate, an intermediate of novel antiarteriosclerotics, via a safe, scalable reformatsky-type reaction
Osato, Hiroshi,Osaki, Motonari,Oyama, Takao,Takagi, Youhei,Hida, Takemasa,Nishi, Koichi,Kabaki, Mikio
, p. 1433 - 1437 (2011)
Reported here is a safe, scalable process via a Reformatsky-type reaction of iminium salt (4) followed by Red-Al reduction giving tert-butyl-4-(2- hydroxyethyl)-4-(pyrrolidin-1-yl)-piperidine-1-carboxylate (6), an intermediate of novel antiarteriosclerotics (1). The key points of this safe process are the use of trifluoroacetic acid (TFA) for the iminium salt formation, vigorous stirring for the Reformatsky reaction, and slow addition of methyl bromoacetate. Pilot manufacturing on the 500 L scale was achieved.
