694500-01-1Relevant academic research and scientific papers
Synthesis and Biological Evaluation of 1,2,4-Triazole Thioethers as Both Potential Virulence Factor Inhibitors against Plant Bacterial Diseases and Agricultural Antiviral Agents against Tobacco Mosaic Virus Infections
Fang, Zi-Mian,Guo, Deng-Xuan,Ji, Jin,Liu, Li-Wei,Qi, Pu-Ying,Shao, Wu-Bin,Wang, Jin-Jing,Wang, Pei-Yi,Yang, Song,Zhou, Xiang
, p. 15108 - 15122 (2021/12/27)
Targeting the virulence factors of phytopathogenic bacteria is an innovative strategy for alleviating or eliminating the pathogenicity and rapid outbreak of plant microbial diseases. Therefore, several types of 1,2,4-triazole thioethers bearing an amide l
Diazole thioether compounds containing amide substructure as well as preparation method and application thereof
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Paragraph 0051; 0052; 0053; 0056; 0063; 0064; 0067; 0068, (2021/11/10)
The invention relates to diazole thioether compounds containing an amide substructure as well as a preparation method and application thereof. The compounds have a structure as shown in a general formula (I) in the specification; 1, 2, 4-triazole thioether or 1, 3, 4-thiadiazole/oxadiazole thioether is used as a basis, and an amino-containing structural fragment is introduced into the system to synthesize a series of amide-substructure-containing 1, 2, 4-triazole thioether and 1, 3, 4-thiadiazole/oxadiazole thioether compounds; and the compounds have an excellent inhibition effect on plant pathogenic bacteria, tobacco mosaic viruses and the like.
Synthesis and biological studies of N-phenyl substituted 2-(-5-(pyridine-4-yl)-1,3,4-oxadiazole-2-yl thio)acetamides
Rao, M.E. Bhanoji,Rajurkar, Vikas G.
experimental part, p. 2648 - 2652 (2012/01/05)
As oxadiazole have proven to be good antimicrobial agents, Antitubercular, analgesic (peripheral and central) and antiinflammatory agents. A new series of oxadiazole derivatives were synthesized and characterized by 1H NMR, IR, GCMS sophisticated analytical instruments and were evaluated for their antimicrobial activity, antitubercular activity, toxicity as per standard guidelines, analgesic (peripheral and central) and antiinflammatory activity. Out of several derivatives synthesized a few of N-phenyl substituted 2-(5-(pyridine-4- yl)-1,3,4-oxadiazole-2-yl thio)acetamide explores good antimicrobial activity by using Cup-Plate method, antitubercular activity by middle brook 7H9 agar medium against H37Rv, analgesic activity by Writhing and Tail immersion method and antiinflammatory by rat paw edema method.
