694529-80-1

Upstream product

• 70-69-9 1-(4-aminophenyl)-1-propanone 
• 124-63-0 methanesulfonyl chloride 
• 1197-22-4 N-phenylmethanesulfonamide 
• 123-62-6 propionic acid anhydride 

Downstream Products

• 910486-64-5 N-[4-((1R)-1-{[(R)-tert-butylsulfinyl]amino}propyl)phenyl]methanesulfonamide 
• 694529-54-9 N-[4-(1-amino-propyl)-phenyl]-methanesulfonamide 
• 694529-45-8 N-[4-(1-hydroxyimino-propyl)-phenyl]-methanesulfonamide 

Relevant academic research and scientific papers

Chain-branched 1,3-dibenzylthioureas as vanilloid receptor 1 antagonists

A series of chain-branched 1,3-dibenzylthiourea derivatives were synthesized, and tested their antagonist activity against vanilloid receptor 1. Chain-branching led to a significant change in the mode of action and the potency. (R)-Methyl or ethyl-branched 1,3-dibenzylthiourea derivatives showed the most potent antagonist activity up to the IC50 value of 0.05 μM which is 10-fold more potent than capsazepine.

Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides

The present invention provides novel sulfonanilide and benzene-alkylaminium compounds which are the products of processes utilizing novel intermediates. Both the novel compounds and the novel intermediates are useful for the therapeutic or prophylactic treatment of arrhythmic activity.