69471-12-1

Upstream product

• 91-10-1 1,3-dimethoxy-2-hydroxy-benzene 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 944-99-0 acetic acid 2,6-dimethoxy-phenyl ester 
• 4393-06-0 1-Phenyl-2-propen-1-ol 
• 100-52-7 benzaldehyde 
• 69471-01-8 3-benzyloxy-2-hydroxy-4-methoxy-acetophenone 
• 69471-02-9 3-benzyloxy-2,4-dimethoxyacetophenone 
• 69471-06-3 3-Benzyloxy-2',4'-dimethoxychalcon 

Relevant academic research and scientific papers

Synthetic method of 1,3-substituted Diphenylpropenes

The present invention relates to a method for efficiently synthesizing a natural 1,3-substituted diphenylpropene compound having biological activity. The effective method synthesizes 1,3-substituted diphenylpropene compound 1 to 4 using Friedel-Crafts alk

Syntheses and anti-inflammatory activity of natural 1,3-diarylpropenes

First syntheses of five natural 1,3-diarylpropenes (cinnamylphenols) 2-4, 7, and 8 along with synthesis of two other natural 1,3-diarylpropenes 1 and 5 and E-isomer of mucronulastyrene (6) were achieved by Friedel- Crafts alkylation as a key step. Subsequ

Synthetic cinnamylphenol derivatives as cancer chemopreventive agents

Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters).

Inhibitors of prostaglandin biosynthesis from Dalbergia odorifera

The root heartwood of Dalbergia odorifera T. CHEN (Leguminosae) is a Chinese medicinal drug (Japanese name koshinko) used for a stagnant blood syndrome (stagnation of disordered blood; Japanese, oketsu). In addition to 10 known compounds, five new phenolic compounds, isomucronustyrene and hydroxyobtustyrene (cinnamylphenols), (+)-isoduartin (isoflavan), odoriflavene (isoflav-3-ene) and (-)-odoricarpan (pterocarpan) were isolated and their structures were elucidated on the basis of chemical and spectroseopic methods. Of the fifteen compounds isolated, cinnamylphenols, isoflavans, isoflavene and benzoic acid derivative significantly inhibited prostaglandin biosynthesis as well as platelet aggregation induced by arachidonic acid.