944-99-0

Basic information

• Product Name: 2,6-DIMETHOXYPHENYLACETATE
• Synonyms: 2,6-DIMETHOXYPHENYLACETATE;2,6-Dimethoxyphenol acetate;Acetic acid 2,6-dimethoxyphenyl ester;(2,6-dimethoxyphenyl) ethanoate
• CAS NO: 944-99-0
• Molecular Formula: C₁₀H₁₂O₄
• Molecular Weight: 196.2
• Product Categories: Aromatic Esters
• Mol File: 944-99-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 53.5 °C
• Boiling Point: 228.8°Cat760mmHg
• Flash Point: 91.4°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 0.0719mmHg at 25°C
• Refractive Index: 1.493
• CAS DataBase Reference: 2,6-DIMETHOXYPHENYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIMETHOXYPHENYLACETATE(944-99-0)
• EPA Substance Registry System: 2,6-DIMETHOXYPHENYLACETATE(944-99-0)

Safety Data

• Hazardous Substances Data: 944-99-0(Hazardous Substances Data)

Usage

General Description

2,6-DIMETHOXYPHENYLACETATE, also known as veratrate, is an organic compound with the chemical formula C10H12O4. It is a derivative of veratric acid, which is found in a variety of plants. 2,6-DIMETHOXYPHENYLACETATE is commonly used in the pharmaceutical industry as a starting material for the synthesis of various pharmaceuticals, including cardiovascular drugs. It is also used as a building block in the synthesis of natural products and other bioactive compounds. Furthermore, this compound has potential applications in the fields of organic and medicinal chemistry due to its structural and pharmacological properties.

InChI:InChI=1/C10H12O4/c1-7(11)14-10-8(12-2)5-4-6-9(10)13-3/h4-6H,1-3H3

Upstream product

• 91-10-1 1,3-dimethoxy-2-hydroxy-benzene 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 7664-93-9 sulfuric acid 
• 201230-82-2 carbon monoxide 
• 74-88-4 methyl iodide 
• 634-36-6 1,2,3-trimethoxybenzene 
• 2040-04-2 2,6-dimethoxyacetophenone 

Downstream Products

• 69471-12-1 (E)-3-cinnamyl-2,6-dimethoxyphenol 
• 1226854-44-9 1-(4''-hydroxyphenyl)-3-(3'-hydroxy-2',4'-dimethoxyphenyl)propene 
• 90003-98-8 3-Iod-2,6-dimethyl-phenol 
• 861304-47-4 2,3,4-trimethoxy-1,5-dinitro-benzene 
• 122756-24-5 4.6-dinitro-pyrogallol-1.3-dimethyl ether 
• 80894-08-2 acetic acid-(3-amino-2,6-dimethoxy-phenyl ester) 
• 32904-64-6 2,6-Dimethoxy-3-nitro-phenol 
• 102872-41-3 1,2,3-trimethoxy-4-nitro-benzene 
• 101878-61-9 4-nitro-benzoic acid-(4-ethyl-2,6-dimethoxy-phenyl ester) 

Relevant articles and documents

An efficient method to prepare aryl acetates by the carbonylation of aryl methyl ethers or phenols

Synthesis of valuable chemicals from lignin based compounds is critical for the application of biomass. Here, we develop a method of preparing aryl acetates by the carbonylation of aryl methyl ethers or phenols under low CO pressure. Good to excellent yields of aryl acetates were obtained using different substrates, and a possible reaction mechanism was proposed by conducting a series of control experiments. This method may provide a potential way for the utilization of lignin.

Synthetic method of 1,3-substituted Diphenylpropenes

The present invention relates to a method for efficiently synthesizing a natural 1,3-substituted diphenylpropene compound having biological activity. The effective method synthesizes 1,3-substituted diphenylpropene compound 1 to 4 using Friedel-Crafts alk

The Baeyer-Villiger oxidation versus aromatic ring hydroxylation: Competing organic peracid oxidation mechanisms explored by multivariate modelling of designed multi-response experiments

Peroxy acids can be used as the terminal oxidant for the Baeyer-Villiger oxidation of acetophenones and for direct ring hydroxylation of methoxy-substituted benzenes. An oxidative system involving 3-chloroperbenzoic acid (mCPBA) and 2,6-dimethoxyacetophenone as model substrate was investigated by means of statistical experimental design, multivariate modelling and response surface methodology. The outcome of the organic peracid oxidation experiments was portrayed by a multi-response matrix consisting of the yields of three different compounds; 2,6-dimethoxyphenyl acetate, 1-(4-hydroxy-2,6-dimethoxy-phenyl)ethanone and 3-hydroxy-2,6-dimethoxy-phenyl acetate. The optimized reaction protocol was utilized to investigate a series of various substituted acetophenones. The overall investigation revealed that both the molecular structure of the acetophenone substrate and the experimental conditions exhibited a substantial impact on whether the oxidation reaction follows the oxygen insertion or direct ring hydroxylation mechanism. An improved protocol for the direct ring hydroxylation was also obtained from the experimental and modelling described herein.