6948-75-0

Usage

Type of Compound

Synthetic cannabinoid

Function

Potent agonist of the CB1 receptor

Original Purpose

Potential medication for multiple sclerosis and cancer

Adverse Effects

Agitation, hallucinations, and seizures

Abuse Potential

High

Legal Status

Banned in several countries

Schedule in the United States

Schedule I controlled substance

Legality

Illegal to manufacture, distribute, or possess for any purpose in the United States

Upstream product

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• 3179-10-0 1-methoxy-4-(2-nitro-vinyl)-benzene 
• 27570-08-7 4-(2-bromo-vinyl)-anisole 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Relevant academic research and scientific papers

Cobalt-Catalyzed Reductive Cross-Coupling Between Styryl and Benzyl Halides

A simple and efficient protocol for the direct reductive cross-coupling between alkenyl and benzyl halides using a Co/Mn system has been developed. This reaction proceeds smoothly in the presence of [CoBr2(PPh3)2] as the catalyst, with NaI as an additive in acetonitrile with a broad scope of functionalized alkenyl and benzyl halides. Different functional groups are tolerated on both coupling partners, thus, significantly extending the general scope of transition-metal-catalyzed benzylation of alkenyl halides. Moderate to excellent yields were also obtained. From a mechanistic point of view, a radical chain mechanism was proposed. This reaction is stereospecific and some studies suggest the retention of the double-bond configuration.

Alkyl transfer from C-C cleavage: Replacing the nitro group of nitro-olefins

Alkyl substituted Hantzsch esters are rationally used as alkylation reagents to replace the nitro groups of nitro olefins to give excellent yields of trans-olefins. The reaction mechanism is considered to proceed through a free radical mechanism, which is different from the corresponding transfer alkylation of imines. This journal is the Partner Organisations 2014.

Direct olefination of benzaldehydes into 1,3-diarylpropenes via a copper-catalyzed heterodomino Knoevenagel-decarboxylation-Csp3-H activation sequence

Copper-catalyzed direct olefination of benzaldehydes into 1,3-diarylpropenes by a novel domino Knoevenagel-decarboxylation-Csp 3-H activation sequence is reported. This method provides a concise and effective route toward the synthesis of unsymmetrical 1,3-diarylpropene derivatives. the Partner Organisations 2014.

Copper-catalyzed decarboxylative C(sp2)-C(sp3) coupling reactions via radical mechanism

We have successfully developed an example of copper-catalyzed decarboxylative C(sp2)-C(sp3) coupling reactions via C-H functionalization for the first time. It is noteworthy that our catalytic system is very stable, low-cost, palladium-free, ligand-free, and easily accessible.