695-19-2

Basic information

• Product Name: 1-Methyl-4(1H)-pyridinone
• Synonyms: 1-Methyl-4(1H)-pyridinone;1-Methyl-1,4-dihydropyridine-4-one;1-Methyl-4(1H)-pyridone;1-Methyl-4-pyridone;1-Methylpyridine-4(1H)-one;1-Methyl-4-oxopyridine;N-Methyl-4-pyridone;4(1H)-Pyridinone, 1-Methyl-
• CAS NO: 695-19-2
• Molecular Formula: C₆H₇NO
• Molecular Weight: 109.13
• Product Categories: Aromatics;Catalyst;Heterocycles;Intermediates
• Mol File: 695-19-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 204.59°C (rough estimate)
• Flash Point: 66.2°C
• Appearance: /
• Density: 1.1143 (rough estimate)
• Vapor Pressure: 1.15mmHg at 25°C
• Refractive Index: 1.5180 (estimate)
• Storage Temp.: Amber Vial, Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 1-Methyl-4(1H)-pyridinone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-4(1H)-pyridinone(695-19-2)
• EPA Substance Registry System: 1-Methyl-4(1H)-pyridinone(695-19-2)

Safety Data

• Hazardous Substances Data: 695-19-2(Hazardous Substances Data)

Usage

Uses

1-Methyl-4-pyridone is used as a catalyst in acylation reactions as well as in the preparation of phosphorus-containing thiosemicarbazides.

InChI:InChI=1/C6H7NO/c1-7-4-2-6(8)3-5-7/h2-5H,1H3

Upstream product

• 620-08-6 4-methoxypyridine 
• 127427-45-6 2-bromo-2,2-difluoro-N-phenyl-acetamide 
• 186581-53-3 diazomethane 
• 2301-80-6 N-methyl-4-methylpyridinium iodide 
• 13441-45-7 N-methyl-4-cyanopyridinium 

Downstream Products

• 35488-00-7 1-methyl-2,3-dihydro-4-pyridone 
• 99794-22-6 2-benzoyl-1-methyl-4-pyridone 
• 99794-21-5 2-(1-hydroxyphenylmethyl)-1-methyl-4-pyridone 
• 99794-20-4 2-benzyl-1-methyl-4-pyridone 
• 99794-25-9 1-methyl-2-(1,2-diphenylethyl)-4-pyridone 
• 115177-86-1 2-hydroxydiphenylmethyl-1-methyl-4-pyridone 
• 99794-23-7 2-(2-carboxyphenylcarbonyl)-1-methyl-4-pyridone 
• 99794-26-0 2-(2-hydroxymethylbenzoyl)-1-methyl-4-pyridone 
• 99794-27-1 cyclic hemiacetal 
• 6887-59-8 1-methylpyridine-4(1H)-thione 
• 106-52-5 N-methyl-4-hydroxypiperidine 
• 760-67-8 2-ethylhexanoic acid chloride 
• 33445-17-9 cyclohexyl-hydroxy-phenyl-acetic acid-(1-methyl-[4]piperidyl ester) 
• 37830-21-0 cyclopentyl-hydroxy-phenyl-acetic acid-(1-methyl-[4]piperidyl ester) 

Relevant articles and documents

Slicing and Splicing of Bromodifluoro-N-arylacetamides: Dearomatization and Difunctionalization of Pyridines

Copper-catalyzed dearomatization and difunctionalization of pyridines have been disclosed, in which bromodifluoro-N-arylacetamide was sliced into five fragments and three or four of them were transferred to pyridine partners. Through this reaction, novel N-difluoromethyl-2-imine dihydropyridine derivatives can be conveniently accessed from commercially available 4-amino substituted pyridines. This strategy demonstrates a novel fluorination method featuring high atom economy, environmental friendliness, an easily available catalyst, and simple operation.

2- and 4-Pyridones by Oxidative Demethylation of 2- and 4-Methylpyridinium Cations

1-Substituted-2- and -4-methylpyridinium cations are converted by pentyl or ethyl nitrite and sodium methoxide into 1-substituted-2- and -4-pyridones respectively.