695-37-4

Basic information

• Product Name: 3-FLUOROPYRIDINE N-OXIDE
• Synonyms: 3-FLUOROPYRIDINE N-OXIDE;3-fluoro-1-oxidanidyl-pyridin-1-ium;3-fluoro-1-oxido-pyridin-1-ium;3-fluoro-1-oxidopyridin-1-ium;3-fluoro-1$l^{5}-pyridin-1-one
• CAS NO: 695-37-4
• Molecular Formula: C₅H₄FNO
• Molecular Weight: 113.09
• EINECS: 1533716-785-6
• Product Categories: Fluorin-contained pyridine series;Pyridine;Pyridines;Fluorine series;alkyl Fluorine
• Mol File: 695-37-4.mol
• Article Data: 21

Chemical Properties

• Melting Point: 65-68°C
• Boiling Point: 275℃
• Flash Point: 120℃
• Appearance: /
• Density: 1.18
• Vapor Pressure: 0.00892mmHg at 25°C
• Refractive Index: 1.494
• PKA: 0.16±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-FLUOROPYRIDINE N-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUOROPYRIDINE N-OXIDE(695-37-4)
• EPA Substance Registry System: 3-FLUOROPYRIDINE N-OXIDE(695-37-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 695-37-4(Hazardous Substances Data)

Usage

General Description

3-Fluoropyridine N-oxide is a chemical compound with the molecular formula C5H4FNO. It is a crystalline solid that is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. 3-FLUOROPYRIDINE N-OXIDE is also known for its use as a reagent in organic synthesis, particularly for the preparation of heterocyclic compounds. 3-Fluoropyridine N-oxide is known for its mild toxicity and limited environmental impact, making it a favorable choice for many industrial and research applications.

InChI:InChI=1/C5H4FNO/c6-5-2-1-3-7(8)4-5/h1-4H

Upstream product

• 2402-97-3 3-bromopyridine N-oxide 
• 372-47-4 3-Fluoropyridine 

Downstream Products

• 151373-12-5 (1-oxy-pyrid-3-ylsulphanyl)-acetic acid methyl ester 
• 372-47-4 3-Fluoropyridine 
• 89959-07-9 MoO₂(2,6-bis(2,2-diphenyl-2-mercaptoethyl)pyridine^(2-)) 
• 1127562-52-0 2-(3,5-dimethylphenyl)-3-fluoropyridine 1-oxide 
• 14906-61-7 3-methoxypyridine N-oxide 
• 7295-76-3 3-methoxypyridine 
• 1620125-42-9 5-fluoro-2-(1-(3-methylbenzyl)-1H-1,2,3-triazol-5-yl)pyridine 1-oxide 
• 1449307-72-5 2-(3-fluoropyridin-1-ium-1-yl)phenolate 
• 1262526-36-2 2-(4-methoxycarbonylphenyl)-3-fluoropyridine 1-oxide 
• 1262526-31-7 2-(3,5-dimethoxyphenyl)-3-fluoropyridine 1-oxide 
• 1262526-27-1 2-(4-t-butylphenyl)-fluoropyridine 1-oxide 
• 1262526-29-3 3-fluoro-2-(3-methoxyphenyl)pyridine 1-oxide 
• 1262526-28-2 2-{3-(N,N-dimethylamino)phenyl}-3-fluoropyridine 1-oxide 
• 1262526-30-6 3-fluoro-2-(3-methylphenyl)pyridine 1-oxide 

Relevant articles and documents

Visible-Light-Induced ortho-Selective Migration on Pyridyl Ring: Trifluoromethylative Pyridylation of Unactivated Alkenes

The photocatalyzed ortho-selective migration on a pyridyl ring has been achieved for the site-selective trifluoromethylative pyridylation of unactivated alkenes. The overall process is initiated by the selective addition of a CF3 radical to the alkene to provide a nucleophilic alkyl radical intermediate, which enables an intramolecular endo addition exclusively to the ortho-position of the pyridinium salt. Both secondary and tertiary alkyl radicals are well-suited for addition to the C2-position of pyridinium salts to ultimately provide synthetically valuable C2-fluoroalkyl functionalized pyridines. Moreover, the method was successfully applied to the reaction with P-centered radicals. The utility of this transformation was further demonstrated by the late-stage functionalization of complex bioactive molecules.

Preparation method of halogenated pyridine type nitrogen oxide

The invention discloses a preparation method of a halogenated pyridine type nitrogen oxide. The method comprises the following steps: (1) dissolving a raw material halogenated pyridine into a solvent,adding a certain amount of an oxidizing agent, performing a reaction in a range of a reaction temperature of 0 to 40 DEG C, and after the reaction ends, obtaining a reaction product; (2) performing asubsequent postprocessing step on the reaction product obtained in the step (1) so as to obtain the target product halogenated pyridine type nitrogen oxide. The preparation method disclosed by the invention has the advantages of low reaction temperature, high yield, high purity, low cost and the like.

SYNTHESIS OF META-SUBSTITUTED [18F]-3-FLUORO-4-AMINOPYRIDINES BY DIRECT RADIOFLUORINATION OF PYRIDINE N-OXIDES

Disclosed herein are methods for the fluorination aromatic N-heterocyclic N-oxides that comprise at least one leaving group. The N-oxides may be reduced to the fluorinated aromatic N-heterocyclic amine analogs. This novel fluorination approach may be successfully applied for synthesizing aromatic N-heterocyclic compounds labeled with 18F.