14906-61-7

Basic information

• Product Name: 3-METHOXYPYRIDINE 1-OXIDE
• Synonyms: 3-Methoxypyridine N-oxide;3-methoxy-1-oxidopyridin-1-ium;Pyridine, 3-methoxy-,1-oxide;Pyridinium,1-hydroxy-3-methoxy-,hydroxide,inner salt;3-METHOXYPYRIDINE 1-OXIDE
• CAS NO: 14906-61-7
• Molecular Formula: C₆H₇NO₂
• Molecular Weight: 125.13
• Mol File: 14906-61-7.mol
• Article Data: 13

Chemical Properties

• Melting Point: 100-101 °C
• Boiling Point: 308.928 °C at 760 mmHg
• Flash Point: 140.635 °C
• Appearance: /
• Density: 1.097 g/cm³
• Vapor Pressure: 0.0012mmHg at 25°C
• Refractive Index: 1.501
• PKA: 0.84±0.10(Predicted)
• CAS DataBase Reference: 3-METHOXYPYRIDINE 1-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXYPYRIDINE 1-OXIDE(14906-61-7)
• EPA Substance Registry System: 3-METHOXYPYRIDINE 1-OXIDE(14906-61-7)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 14906-61-7(Hazardous Substances Data)

Usage

General Description

3-Methoxypyridine 1-oxide is a chemical compound with the molecular formula C6H7NO2. It is a colorless liquid that is commonly used as a reagent in organic synthesis and as a precursor in the production of pharmaceuticals and agrochemicals. It is known for its unique ability to undergo a variety of chemical reactions, making it a valuable tool in the development of new compounds and materials. Additionally, its high reactivity and stability make it an important component in the field of chemical research and development. Due to its versatile applications, 3-Methoxypyridine 1-oxide continues to be of interest to chemists and researchers seeking to expand the potential of this valuable chemical compound.

InChI:InChI=1/C6H7NO2/c1-9-6-3-2-4-7(8)5-6/h2-5H,1H3

Upstream product

• 1851-22-5 3-chloropyridine-N-oxide 
• 124-41-4 sodium methylate 
• 2402-97-3 3-bromopyridine N-oxide 
• 695-37-4 3-fluoropyridine-1-oxide 
• 372-47-4 3-Fluoropyridine 
• 626-55-1 3-Bromopyridine 
• 865-33-8 potassium methanolate 
• 75-09-2 dichloromethane 
• 109-00-2 3-HYDROXYPYRIDINE 
• 120309-63-9 C₅₆H₉₈O₃₅*C₆H₇NO₂ 
• 7295-76-3 3-methoxypyridine 
• 93-59-4 Perbenzoic acid 
• 186581-53-3 diazomethane 
• 6602-28-4 3-hydroxypyridine N-oxide 

Downstream Products

• 19355-04-5 3-methoxy-4-nitropyridine 1-oxide 
• 1274856-63-1 2-(4-tert-butylphenoxy)-3-methoxypyridine 
• 1219601-22-5 C₈H₈N₄O 
• 1219601-23-6 C₈H₈N₄O 
• 141667-62-1 2-(p-toluenesulfonyloxy)-3-methoxy-pyridine 
• 1127562-38-2 C₁₄H₁₅NO₂ 
• 1127562-36-0 2-(3,5-dimethylphenyl)-5-methoxypyridine 1-oxide 
• 1174000-57-7 2,6-bis(3,5-dimethylphenyl)-3-methoxypyridine 1-oxide 
• 1092694-65-9 2-(carboxylic acid phenylamide)-3-methoxypyridine 1-oxide 
• 1092694-37-5 3-methoxy-2-(phenylmethanol)pyridine 1-oxide 
• 1092694-54-6 2-(cyclohexyl-1-ol)-3-methoxypyridine 1-oxide 
• 109911-41-3 5-Methoxy-1-methyl-4-o-tolyl-1,2,3,6-tetrahydro-pyridine 
• 109911-39-9 3-Methoxy-4-o-tolyl-pyridine 
• 109911-37-7 4-bromo-3-methoxypyridine 1-oxide 

Relevant articles and documents

One step conversion of heteroaromatic-N-oxides to imidazolo-heteroarenes

(Chemical Equation Presented) Various pyridine-, quinoline-, isoquinoline-, and pyrimidine-N-oxides were converted to their corresponding α-imidazoloheteroarenes in good yield by treatment with sulfuryl diimidazole in nonpolar solvents at elevated tempera

Synthesis method of heterocyclic compound 3-methoxypyridine

The invention discloses a synthesis method of a heterocyclic compound 3-methoxypyridine. The method comprises the following steps: putting raw materials, i.e., 3-halogenated pyridine, hydrogen peroxide and acetic acid into a three-mouth flask, carrying out reaction for 4-8h at the temperature of 40-80 DEG C under the condition of stirring, recovering the acetic acid, adding a saturated sodium carbonate solution and stirring to enable a system to be alkaline, evaporating to remove water, then adding chloroform for washing, and carrying out vacuum distillation to obtain N-oxide-3-halogenated pyridine; respectively adding the N-oxide-3-halogenated pyridine, metal salt of alkyl alcohol, a catalyst A and alcohol into the three-mouth flask, carrying out reflux reaction for 5-8h under the condition of stirring, then cooling, neutralizing a product to be neutral, and carrying out distillation to obtain N-oxide-3-alkyloxypyridine; respectively adding the N-oxide-3-alkyloxypyridine, ferric trichloride, hydrazine hydrate, activated carbon and ethanol into the three-mouth flask, carrying out reaction at the temperature of 70 DEG C for 3h, cooling to room temperature, and carrying out vacuum distillation to obtain the 3-methoxypyridine. The synthesis method is high in intermediate conversion rate, mild in reaction conditions, safe in operation, low in price of raw materials and easy in raw material obtaining, thus being suitable for industrial production.

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