6952-34-7

Basic information

• Product Name: 2-(4-HYDROXYPHENYL)QUINOLINE-4-CARBOXYLIC ACID
• Synonyms: AKOS B000548;2-(4-HYDROXYPHENYL)QUINOLINE-4-CARBOXYLIC ACID;CHEMBRDG-BB 5349475;TIMTEC-BB SBB001025;4-quinolinecarboxylic acid, 2-(4-hydroxyphenyl)-;2-(4-hydroxyphenyl)quinoline-4-carboxylic acid(SALTDATA: FREE)
• CAS NO: 6952-34-7
• Molecular Formula: C₁₆H₁₁NO₃
• Molecular Weight: 265.26
• Mol File: 6952-34-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 500.997 °C at 760 mmHg
• Flash Point: 256.794 °C
• Appearance: /
• Density: 1.374 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.712
• CAS DataBase Reference: 2-(4-HYDROXYPHENYL)QUINOLINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-HYDROXYPHENYL)QUINOLINE-4-CARBOXYLIC ACID(6952-34-7)
• EPA Substance Registry System: 2-(4-HYDROXYPHENYL)QUINOLINE-4-CARBOXYLIC ACID(6952-34-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 6952-34-7(Hazardous Substances Data)

Usage

General Description

2-(4-Hydroxyphenyl)quinoline-4-carboxylic acid is a chemical compound with the molecular formula C17H11NO3. It is a derivative of quinoline and contains a carboxylic acid functional group and a hydroxyphenyl group. 2-(4-HYDROXYPHENYL)QUINOLINE-4-CARBOXYLIC ACID is often used in pharmaceutical research and drug development due to its potential pharmacological properties. It has been studied as a potential anti-cancer agent and has shown activity against various cancer cell lines in experimental studies. Additionally, 2-(4-Hydroxyphenyl)quinoline-4-carboxylic acid has also been investigated for its potential as an antimicrobial and antiviral agent. Its unique chemical structure and potential biological activities make it a subject of interest in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C16H11NO3/c18-11-7-5-10(6-8-11)15-9-13(16(19)20)12-3-1-2-4-14(12)17-15/h1-9,18H,(H,19,20)

Upstream product

• 4364-02-7 2-(4-methoxyphenyl)quinoline-4-carboxylic acid 
• 91-56-5 indole-2,3-dione 
• 99-93-4 4-Hydroxyacetophenone 
• 123-08-0 4-hydroxy-benzaldehyde 
• 127-17-3 2-oxo-propionic acid 
• 62-53-3 aniline 
• 99-90-1 para-bromoacetophenone 
• 103914-52-9 2-(4'-bromophenyl)quinoline-4-carboxylic acid 
• 350997-62-5 methyl 2-(4'-bromophenyl)-quinoline-4-carboxylate 

Downstream Products

• 39654-23-4 2-(4-hydroxy-phenyl)-1-methyl-quinolinium; iodide 
• 30696-03-8 2-(4-hydroxyphenyl)quinoline 

Relevant articles and documents

A new boronic acid based fluorescent reporter for catechol

Catechol skeleton widely exists in natural products and bioactive substances. Fluorescent reporters which could recognize catechol are very promising for the construction of chemosensors to detect catechol and its derivatives in biological environment. Herein, we reported a novel catechol reporter, 2-(4-boronophenyl)quinoline-4-carboxylic acid, which exhibits significant fluorescent property changes upon binding catechol containing molecules in an aqueous solution.

A highly selective and sensitive boronic acid-based sensor for detecting Pd2+ ion under mild conditions

Herein, a boronic acid-based sensor was reported selectively to recognize Pd2+ ion. The fluorescence intensity increased 36-fold after sensor binding with 2.47 × 10?5 M of Pd2+ ion. It was carried out in the 99% aqueous so

A novel boronic acid-based fluorescent sensor for selectively recognizing Fe3+ ion in real time

Boronic acid provides faster fluorescence response to Fe3+ compared to other reported sensors, which is critical for continuous dynamic detection. Herein, we reported a novel boronic acid-based sensor 4 that could recognize Fe3+ ion in real time. After 10 equiv. of Fe3+ ion (1 mM) was added, the fluorescence of sensor 4 was immediately quenched by 96%. While other ions, including Ba2+, Ca2+, Cr2+, Cd2+, Co2+, Cs2+, Cu2+, Fe2+, K+, Li+, Mg2+, Mn2+, Na+, Ni2+ or Zn2+, respectively, did not change the fluorescence significantly. Further tests indicated that the high selectively sensing Fe3+ ion benefits from the two boronic acid functionalities in the structure. Moreover, interference experiments showed this sensor has an excellent anti-interference ability. In addition, we performed binding activity test in rabbit plasma and other real samples for practical applications, obtaining similar results. And the thin layer loading sensor 4 was also successfully applied to recognize Fe3+ ion among various ions. Therefore, 4 may serve as a potential sensor for continuous monitoring and detecting Fe3+ ion in real time.