30696-03-8Relevant academic research and scientific papers
A supramolecular self-assembly material based on a quinoline derivative and its sensitive response toward volatile acid and organic amine vapors
Cao, Xinhua,Ding, Qianqian,Gao, Aiping,Li, Yiran,Chang, Xueping,Wu, Yongquan
, p. 6305 - 6314 (2018)
A new gelator 1, containing a quinoline group, was designed, synthesized, and fully characterized. It was found that a stable organogel of 1 could be obtained in some solvents, including ethanol, acetonitrile, n-hexane, petroleum ether, and DMSO. It is wo
Triethylene glycol-modified iridium(III) complexes for fluorescence imaging of: Schistosoma japonicum
Wu, Yongquan,Zeng, Guanjie,Lvyue, Nannan,Wu, Weihua,Jiang, Tianyu,Wu, Rongle,Guo, Wei,Li, Xun,Fan, Xiaolin
, p. 4973 - 4980 (2017)
Schistosomiasis, an infectious disease caused by the Schistosoma parasitic worm, presents a serious public health issue. To date, investigation of anti-Schistosomiasis drug mechanisms through fluorescence imaging remains challenging due to the lack of appropriate dyes as fluorescent probes. Phosphorescent Ir(iii) complexes have been attracting substantial attention among various classes of fluorophores given their excellent photophysical properties. Herein, four phosphorescent Ir(iii) complexes were synthesized, two of which contained a triethylene glycol (TEG) hydrophilic group. The phosphorescent emission range of the four complexes lay between 500 and 750 nm, and their quantum yields ranged from 0.031 to 0.146. Furthermore, under the experimental concentration conditions, the TEG-modified complexes had low cytotoxicity. Cell fluorescence labeling experiments indicated that the TEG-modified complexes had good membrane permeability. Finally, the TEG-modified complexes showed remarkable labeling effects in adult Schistosoma fluorescence imaging. Thus, TEG-modified Ir(iii) complexes could be used as a new class of bilharzial fluorescent probes.
On-Water Synthesis of 2-Substituted Quinolines from 2-Aminochalcones Using Benzylamine as the Nucleophilic Catalyst
Lee, So Young,Cheon, Cheol-Hong
, p. 13036 - 13044 (2018/11/20)
On-water synthesis of 2-substituted quinolines from 2-aminochalcone derivatives was developed using benzylamine as the nucleophilic catalyst. Various 2-aminochalcones could be applied to this protocol, and the desired 2-substituted quinoline products were isolated in excellent yields by simple filtration. Furthermore, we elucidated the role of benzylamine in this transformation and provided the detailed reaction mechanism. This protocol has several additional advantages, such as simple operation, broad substrate scope, good functional group tolerance, easy product isolation, recycling of the catalyst, and gram-scale synthesis.
Synthesis and structure of arene ruthenium(II) complexes: One-pot catalytic approach to synthesis of bioactive quinolines under mild conditions
Subramanian, Muthumari,Sundar, Saranya,Rengan, Ramesh
, (2018/10/15)
Efficient catalytic one-step synthesis of substituted quinoline derivatives using newly synthesized Ru(II) half-sandwich complexes of the type [Ru(η6-p-cymene)Cl(L)] (L = pyrrole-2-aldehydehydrazones) under mild conditions is described. The synthesized complexes exhibit excellent catalytic activity towards the coupling of 2-amino alcohol with functionalized ketones and secondary alcohols in the optimal conditions and afforded the corresponding quinoline derivatives. The synthetic pathway proceeds with high atom efficiency via a sequence of acceptorless dehydrogenation and condensation steps. The maximum isolated yield of the product obtained was up to 97% using 0.3?mol% of catalyst loading for 5?h. These findings significantly advance the scope of the synthesis of bioactive heterocyclic compounds from readily available starting materials.
Synthesis of phosphorescent iridium complex and application thereof in schistosome adult worm fluorescence labeling
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Paragraph 0032; 0038, (2017/01/12)
The invention belongs to the field of biological optical labeling for parasitic disease precention and treatment, and relates to synthesis of a phosphorescent iridium complex and application thereof in schistosome adult worm fluorescence labeling. Designi
PdCl2(dppf)-catalyzed in situ coupling of 2-hydroxypyridines with aryl boronic acids mediated by PyBroP and the one-pot chemo- and regioselective construction of two distinct aryl-aryl bonds
Li, Shui-Ming,Huang, Jie,Chen, Guo-Jun,Han, Fu-She
supporting information; experimental part, p. 12840 - 12842 (2012/01/05)
We present a PdCl2(dppf)-catalyzed synthesis of 2-arylated pyridine derivatives via the in situ coupling of 2-OH pyridines and boronic acids mediated by PyBroP. In addition, the highly chemo- and regioselective construction of two different aryl-aryl bonds via a one-pot operation has also been demonstrated by the orthogonal use of this method with the Ni-catalyzed Suzuki-Miyaura coupling of phenols.
