69559-11-1

Basic information

• Product Name: 2-(4-Aminopentyl(ethyl)amino)ethanol
• Synonyms: HYDROXYNOVOLDIAMINE;2-(4-aminopentyl(ethyl)amino)ethanol;5-(N-ETHYL-N-2-ETHOXYLAMINO)-2-PENTYL AMINE;5-(N-Ethyl-N-2-hydroxyethylamino)-2-penthlamine;5-(N-ETHYL-N-2-HYDROXYETHYLAMINO)-2-PENTLAMINE;4-AMINO-N-ETHYL-(2-HYDROXYETHYL)-PENTYLAMINE;HYDROXYNOVOLDIAMINE,5-(N-ETHYL-N-2-HYDROXYETHYLAMINO)-2-PENTHLAMINE;N-Ethyl-N-hydroxyethyl-1,4-pentamethylene diamine
• CAS NO: 69559-11-1
• Molecular Formula: C₉H₂₂N₂O
• Molecular Weight: 174.28
• EINECS: 274-039-9
• Mol File: 69559-11-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 263.6 °C at 760 mmHg
• Flash Point: 113.2 °C
• Appearance: /
• Density: 0.935
• Vapor Pressure: 0.00143mmHg at 25°C
• Refractive Index: 1.470-1474
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.76±0.10(Predicted)
• CAS DataBase Reference: 2-(4-Aminopentyl(ethyl)amino)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Aminopentyl(ethyl)amino)ethanol(69559-11-1)
• EPA Substance Registry System: 2-(4-Aminopentyl(ethyl)amino)ethanol(69559-11-1)

Safety Data

• Hazardous Substances Data: 69559-11-1(Hazardous Substances Data)

Usage

Uses

2-(4-Aminopentyl(ethyl)amino)ethanol is a colorless and pure liquid that can be used as a pharmaceutical intermediate.

InChI:InChI=1/C9H22N2O/c1-3-11(7-8-12)6-4-5-9(2)10/h9,12H,3-8,10H2,1-2H3

Upstream product

• 159346-86-8 R(-)-5--2-pentanamine 
• 74509-79-8 5-(N-ethyl-N-2-hydroxyethylamine)-2-pentanone 
• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 
• 3695-29-2 5-iodo-2-pentanone 

Downstream Products

• 137433-23-9 (R)-Hydroxychloroquine 
• 137433-23-9 (S)-Hydroxychloroquine 
• 118-42-3 hydroxychloroquine 
• 747-36-4 (S)-hydroxychloroquine sulfate 
• 747-36-4 R-(-)-hydroxychloroquine sulfate 
• 747-36-4 Plaquenil 

Relevant articles and documents

Application of chiral chloroquine, hydroxychloroquine or salt of the chiral chloroquine and hydroxychloroquine as anti-coronavirus drug target 3CL hydrolase inhibitor for reducing cardiotoxicity

The invention discloses an application of chiral chloroquine, hydroxychloroquine or pharmaceutically acceptable salts of the chiral chloroquine and hydroxychloroquine in preparation of drugs used forpreventing and/or treating coronavirus pneumonia by using a coronavirus key drug target 3CL hydrolase (Mpro) as an action target. The chiral chloroquine and hydroxychloroquine have high bonding strength with the Mpro causing inflammation of the lung and the like; the activity of the Mpro can be significantly inhibited; and the chiral chloroquine and hydroxychloroquine are indicated to have the effect of preventing and treating pneumonia caused by coronaviruses and be able to be used as anti-pneumonia drugs. Through evaluation on the inhibitory activity of an hERG potassium ion channel, the concentration at which the chloroquine, hydroxychloroquine and enantiomers of the chloroquine and hydroxychloroquine are likely to generate cardiotoxicity to the hERG potassium ion channel is provided. The chiral chloroquine and hydroxychloroquine are prepared through chiral high-performance liquid chromatography and chiral synthesis; S-configuration chloroquine, hydroxychloroquine or salts of the chloroquine and hydroxychloroquine can be selected as a drug independently, or form a pharmaceutical composition for treating diseases caused by the coronaviruses; and due to higher activity and low cardiotoxicity of the chloroquine, hydroxychloroquine or salts of the chloroquine and hydroxychloroquine, the administration dosage range is greatly widened.

HIGH-YIELDING CONTINUOUS FLOW SYNTHESIS OF ANTIMALARIAL DRUG HYDROXYCHLOROQUINE

Cost effective, semi-continuous flow methods and systems for synthesizing the antimalarial drug hydroxychloroquine (HCQ) in high yield are provided. The synthesis method that uses simple, inexpensive reagents to obtain the crucial intermediate 5-(ethyl(2-hydroxyethyl)- amino)pentan-2-one, vertical-integration of the starting material 5-iodopentan-2-one and the integration of continuous stirred tank reactors.