69567-07-3

Upstream product

• 1195847-43-8 (E)-1-(2-benzylidenecyclopropyl)-2-phenylethanone 
• 98-88-4 benzoyl chloride 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 119373-39-6 1-benzylcyclopropan-1-ol 
• 100-39-0 benzyl bromide 
• 43006-71-9 1-(N-Methylanilino)-1-phenylpropen 
• 69567-06-2 (N-methylanilino)prop-2-enenitrile 
• 69567-09-5 C₉H₉LiO 

Downstream Products

• 144193-60-2 5',6'-dihydro-[1,1':2',1''-terphenyl]-3'(4'H)-one 

Relevant academic research and scientific papers

Ruthenium-Catalyzed Alkylation of Cyclopropanols with Sulfoxonium Ylides via C-C Bond Cleavage: Formation of Diverse 1,5-Diketones

A novel ruthenium-catalyzed alkylation of cyclopropanols with sulfoxonium ylides has been developed that affords diverse 1,5-diketones with good efficiency and broad substrate scope. To illustrate the synthetic applications of the obtained 1,5-diketones, aldol and cyclization reactions have been investigated. Preliminary mechanistic studies suggest that this process involves a sequential C C activation and carbene migratory insertion.

Ruthenium-catalyzed room-temperature coupling of α-keto sulfoxonium ylides and cyclopropanols for δ-diketone synthesis

Previous transition metal-catalyzed synthesis processes of δ-diketones are plagued by the high cost of the rhodium catalyst and harsh reaction conditions. Herein a low-cost, room temperature ruthenium catalytic method is developed based on the coupling of α-keto sulfoxonium ylides with cyclopropanols. The mild protocol features a broad substrate scope (47 examples) and a high product yield (up to 99%). Mechanistic studies argue against a radical pathway and support a cyclopropanol ring opening, sulfoxonium ylide-derived carbenoid formation, migratory insertion C-C bond formation pathway.

Ruthenium-catalyzed alkylation reaction of cyclopropanol and sulfur ylide for synthesis of 1, 5-diketone compounds

The invention relates to a ruthenium-catalyzed alkylation reaction of cyclopropanol and sulfur ylide, and a series of 1, 5-diketone compounds can be synthesized by the method. According to the method,cyclopropanol is catalyzed by ruthenium to generate beta-carbon elimination ring opening, and safe, stable and easy-to-prepare sulfur ylide is used as a carbene precursor, so that the method has goodapplicability in the field of construction of 1, 5-diketone.

Pd(0) or Pd(II)-catalyzed ring-opening reactions of benzylidene- and alkylidenecyclopropyl ketones and aldehydes

Pd(0) catalyzed reactions of methylenecyclopropyl carbonyl compounds afforded a convenient method for the synthesis of conjugate (E,E)-1,3-diene derivatives 2 in good to excellent yields. Moreover, we also found that Pd(II)-catalyzed reactions of methylen

1,5-Dicarbonyl Compounds via Michael-Addition of Deprotonated Enamines and Allylamines to 2-(N-Methylanilino) acrylonitrile

A new method for the synthesis of the title compounds by a onepot, three component, coupling reaction is described.Is consists of the reaction of a homoenolate anion and an enol cation equivalent with subsequent alkylation of an acyl-anion equivalent.Hence the methodology of Umpolung is used in a threefold manner within the reaction sequence.